4.7 Article

DNA Methylomes and Epigenetic Age Acceleration Associations with Poor Metabolic Control in T1D

期刊

BIOMEDICINES
卷 9, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/biomedicines9010013

关键词

type 1 diabetes; DNA methylation; PhenoAge; epigenetic aging; age acceleration; metabolic control

资金

  1. Plan Nacional de I+D+I - FEDER [PI18/01527]
  2. Government of the Principality of Asturias PCTI-Plan de Ciencia, Tecnologia e Innovacion de Asturias [IDI/2018/146]
  3. AECC [PROYE18061FERN]
  4. FGCSIC [0348_CIE_6_E]
  5. Spanish Society of Diabetes
  6. IUOPA-ISPA-FINBA - Obra Social Cajastur-Liberbank, Spain
  7. Miguel Servet II fellowship [CPII16/00007]
  8. Severo Ochoa programme (Government of the Principality of Asturias) [BP17-114]

向作者/读者索取更多资源

Through a genome-wide analysis of DNA methylation patterns in T1D patients, it was found that over 100 genes showed DNA methylation differences compared to healthy controls, and only T1D patients with poor glycemic control displayed epigenetic age acceleration.
Type 1 diabetes (T1D) is an autoimmune disease that leads to insulin deficiency and hyperglycemia. Little is known about how this metabolic dysfunction, which substantially alters the internal environment, forces cells to adapt through epigenetic mechanisms. Consequently, the purpose of this work was to study what changes occur in the epigenome of T1D patients after the onset of disease and in the context of poor metabolic control. We performed a genome-wide analysis of DNA methylation patterns in blood samples from 18 T1D patients with varying levels of metabolic control. We identified T1D-associated DNA methylation differences on more than 100 genes when compared with healthy controls. Interestingly, only T1D patients displaying poor glycemic control showed epigenetic age acceleration compared to healthy controls. The epigenetic alterations identified in this work make a valuable contribution to improving our understanding of T1D and to ensuring the appropriate management of the disease in relation to maintaining healthy aging.

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