Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

Neurodegenerative disorders, such as Parkinson's disease (PD), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), are the most concerning disorders due to the lack of effective therapy and dramatic rise in affected cases. Although these disorders have diverse clinical manifestations, they all share a common cellular stress response. These cellular stress responses including neuroinflammation, oxidative stress, proteotoxicity, and endoplasmic reticulum (ER)-stress, which combats with stress conditions. Environmental stress/toxicity weakened the cellular stress response which results in cell damage. Small molecules, such as flavonoids, could reduce cellular stress and have gained much attention in recent years. Evidence has shown the potential use of flavonoids in several ways, such as antioxidants, anti-inflammatory, and anti-apoptotic, yet their mechanism is still elusive. This review provides an insight into the potential role of flavonoids against cellular stress response that prevent the pathogenesis of neurodegenerative disorders.

Automated summary

Neurodegenerative disorders such as PD, AD, ALS, and HD are of great concern due to the lack of effective therapy and increasing number of cases. Small molecules like flavonoids have potential in reducing cellular stress and have gained attention for their antioxidant, anti-inflammatory, and anti-apoptotic properties. Further research is needed to uncover the mechanisms behind the protective effects of flavonoids against cellular stress response in neurodegenerative disorders.