期刊
CANCER & METABOLISM
卷 9, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40170-020-00237-2
关键词
Fatty acid; Lipid; Cellular membrane; De novo synthesis; Lipid droplets; Mitochondria; Peroxisome; Oxidation
资金
- Robinson Fellowship
- University of Sydney
- Australian Research Council [FT130101004]
- Cancer Council SA's Beat Cancer Project
- State Government of South Australia through the Department of Health
- Movember Revolutionary Team Award
- Sydney Catalyst
- Australian Research Council [FT130101004] Funding Source: Australian Research Council
Tumor cellular metabolism has distinguishing features that enhance biomass synthesis and maintain cellular homeostasis through complex interactions between cell-intrinsic and cell-extrinsic factors. Fatty acid metabolism plays a crucial role in tumorigenesis by supporting processes like membrane biosynthesis, energy production, and signaling intermediates generation.
Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation and cell-extrinsic influences, including growth factor and nutrient availability. Alongside glucose and amino acid metabolism, fatty acid metabolism supports tumorigenesis and disease progression through a range of processes including membrane biosynthesis, energy storage and production, and generation of signaling intermediates. Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.
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