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Vineet K. Dhiman et al.
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Thomas M. Ashton et al.
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Brijesh K. Singh et al.
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Adam J. Wolpaw et al.
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Brijesh K. Singh et al.
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Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
R. Kumar et al.
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Paolo Ettore Porporato et al.
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Michael P. Kim et al.
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ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α- Elevated Melanomas
Chi Luo et al.
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Glucose feeds the TCA cycle via circulating lactate
Sheng Hui et al.
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Thomas Farge et al.
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The Mitochondrial Complex(I) ty of Cancer
Felix A. Urra et al.
FRONTIERS IN ONCOLOGY (2017)
Targeting Metabolism for Cancer Therapy
Alba Luengo et al.
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Understanding the Intersections between Metabolism and Cancer Biology
Matthew G. Vander Heiden et al.
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The Role of PGC1α in Cancer Metabolism and its Therapeutic Implications
Zheqiong Tan et al.
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PGC1α drives a metabolic block on prostate cancer progression
Martina Wallace et al.
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ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
Genevieve Deblois et al.
NATURE COMMUNICATIONS (2016)
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Etienne Audet-Walsh et al.
CELL REPORTS (2016)
ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
Sunghee Park et al.
CELL REPORTS (2016)
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
Jiandong Chen
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Fundamentals of cancer metabolism
Ralph J. DeBerardinis et al.
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SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
Thomas T. Vellinga et al.
CLINICAL CANCER RESEARCH (2015)
Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)
Ivan Casaburi et al.
ONCOTARGET (2015)
The Estrogen-Related Receptor α Inverse Agonist XCT 790 Is a Nanomolar Mitochondrial Uncoupler
Banu Eskiocak et al.
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Targeting Estrogen-Related Receptor Alpha Inhibits Epithelial-to-Mesenchymal Transition and Stem Cell Properties of Ovarian Cancer Cells
Sophia S. N. Lam et al.
MOLECULAR THERAPY (2014)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Andrea Viale et al.
NATURE (2014)
PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
Francisca Vazquez et al.
CANCER CELL (2013)
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Rizwan Haq et al.
CANCER CELL (2013)
ERR metabolic nuclear receptor controls growth of colon cancer cells
Gerald Bernatchez et al.
CARCINOGENESIS (2013)
Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors
Brooke M. Emerling et al.
CELL (2013)
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Martin Picard et al.
DIABETES (2013)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
JOURNAL OF CLINICAL INVESTIGATION (2013)
p53 status determines the role of autophagy in pancreatic tumour development
Mathias T. Rosenfeldt et al.
NATURE (2013)
Increased Oxidative Metabolism in the Li-Fraumeni Syndrome
Ping-yuan Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
The PGC-1/ERR signaling axis in cancer
G. Deblois et al.
ONCOGENE (2013)
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond
Genevieve Deblois et al.
NATURE REVIEWS CANCER (2013)
Mutant p53: one name, many proteins
William A. Freed-Pastor et al.
GENES & DEVELOPMENT (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents
Raymond J. Patch et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks
Lillian J. Eichner et al.
MITOCHONDRION (2011)
PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress
Nirmalya Sen et al.
MOLECULAR CELL (2011)
Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response
Rebecca B. Riggins et al.
ENDOCRINE-RELATED CANCER (2010)
Change in serum proteome during allogeneic hematopoietic stem cell transplantation and clinical significance of serum C-reactive protein and haptoglobin
Joohyun Ryu et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2010)
HexServer: an FFT-based protein docking server powered by graphics processors
Gary Macindoe et al.
NUCLEIC ACIDS RESEARCH (2010)
p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment
Zhaohui Feng
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Magali Olivier et al.
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p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content
Joon-Young Park et al.
CIRCULATION RESEARCH (2009)
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
Surojit Sur et al.
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The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
Ralph J. DeBerardinis et al.
CELL METABOLISM (2008)
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Vincent Giguere
ENDOCRINE REVIEWS (2008)
Communication between the ERRα homodimer interface and the PGC-1α binding surface via the helix 8-9 loop
Holger Greschik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds
Marta C. Abad et al.
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Crystal structure of human estrogen-related receptor α in complex with a synthetic inverse agonist reveals its novel molecular mechanism
Joerg Kallen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype:: Lessons from recent developments in the IARC TP53 database
Audrey Petitjean et al.
HUMAN MUTATION (2007)
p53 regulates mitochondrial respiration
Satoaki Matoba et al.
SCIENCE (2006)
Estrogen receptor-α binds p53 tumor suppressor protein directly and represses its function
WS Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
VK Mootha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Estrogen-related receptor α directs peroxisome proliferator-activated receptor at signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
JM Huss et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor α
BB Busch et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand
PJ Willy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor α (ERRα)
SN Schreiber et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
To ERR in the estrogen pathway
V Giguère
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2002)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)