期刊
CLINICAL AND TRANSLATIONAL MEDICINE
卷 10, 期 8, 页码 -出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ctm2.241
关键词
bladder urothelial carcinoma; HuR; MAFG‐ AS1; PTBP1
资金
- National Natural Science Foundation of China [81874137]
- Outstanding Youth Foundation of Hunan Province [2018JJ1047]
- HuxiangYoung Talent Project [2016RS3022]
- Hunan Province Science and Technology Talent Promotion Project [2019TJ-Q10]
- Project of Scientific Research Plan of Health and Family Planning Commission of Hunan Province [c20180476]
- Independent Exploration and Innovation Project of Central South University [2018zzts938]
Long noncoding RNAs (lncRNAs) play a crucial role in progression of bladder urothelial carcinoma (BUC). However, the molecular mechanisms behind this role have not been elucidated yet. Here, we found that the lncRNA MAFG-AS1, which is highly expressed in BUC, is correlated with aggressive characteristics and poor prognosis of BUC. We demonstrate that MAFG-AS1 can promote BUC proliferation, invasion, metastasis, and epithelial-mesenchymal transition in vitro and in vivo. Mechanistically, MAFG-AS1 direct binding to Hu antigen R (HuR) could recruit ubiquitin-specific proteinase 5 (USP5) to prevent HuR from degrading by ubiquitination. We further demonstrate that overexpression of MAFG-AS1 can upregulate the expression of polypyrimidine tract-binding protein 1 (PTBP1) through promoting its stability mediated by bound HuR. In conclusion, these findings indicate that MAFG-AS1 promotes the progression of BUC via regulation of the HUR/PTBP1 axis. Targeting MAFG-AS1 may provide a novel strategy for individualized therapy and a potential biomarker for prognosis of BUC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据