期刊
NATURE CATALYSIS
卷 4, 期 1, 页码 71-78出版社
NATURE PORTFOLIO
DOI: 10.1038/s41929-020-00564-z
关键词
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资金
- National Natural Science Foundation of China [21472033, 21571047, 21672001, 21702041, 21971051, 21871074, 51961135104]
- Key Research and Development Program of Anhui Province [201904a07020069]
- Fundamental Research Funds for the Central Universities [PA2020GDKC0021, JZ2020HGTB0062]
Copper-catalyzed arylboronation is an efficient and versatile carbon-carbon bond formation reaction with potential industrial applications.
Suzuki-Miyaura coupling is a practical and attractive carbon-carbon bond formation reaction due to its high efficiency and wide functional group compatibility, but its industrial applications are limited because it is typically catalysed by expensive palladium-containing transition-metal complexes. Here we show a robust and chemoselective organocatalytic Suzuki-Miyaura-type coupling of aryl halides with arylboronic acids catalysed by amines. The utility and scope of this reaction were demonstrated by the synthesis of several commercially relevant small molecules and a selection of derivatives of pharmaceutical drugs.
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