Membrane tension may define the deadliest virus infection

This manuscript describes the potentially significant role of interfacial tension in viral infection. Our hypothesis is based on evidence from drop coalescence hydrodynamics. A change in membrane tension can trigger fusion between the vesicle and cell such that genetic material, like viral RNA, can subsequently be transported to the cell interior. In other cases, RNA may reside near the cell membrane inside the cell, which could make their removal energetically unfavorable because of hydrodynamic interactions between membrane and RNA. Interfacial tension of the virus membrane can be modulated by temperature, among many other factors, of the mucosa layer. We discuss our hypothesis within the scope of recent SARS-CoV-2 studies where temperature-dependent membrane surface tension could be impacted through different atmospheric conditions, air conditioning systems, and the use of masks.

Automated summary

This manuscript describes the potentially significant role of interfacial tension in viral infection, highlighting the impact of membrane tension changes on viral RNA transportation and the modulation of virus membrane interfacial tension by factors like temperature. The discussion is contextualized within recent SARS-CoV-2 studies, suggesting that membrane surface tension could be influenced by various atmospheric conditions, air conditioning systems, and mask usage.