期刊
FRONTIERS IN VETERINARY SCIENCE
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2020.609443
关键词
TGF-β 1; Mycoplasma bovis; regulatory T cell; immunosuppression; cattle
资金
- JSPS KAKENHI [19KK0172]
- Project of the NARO, Bio-oriented Technology Research Advancement Institution [Research Program on Development of Innovative Technology] [26058 BC]
- Special Scheme Project on Regional Developing Strategy [16817557]
- Grants-in-Aid for Scientific Research [19KK0172] Funding Source: KAKEN
Regulatory T cells (Tregs) regulate immune responses and maintain host immune homeostasis. Tregs contribute to the disease progression of several chronic infections by oversuppressing immune responses via the secretion of immunosuppressive cytokines, such as transforming growth factor (TGF)-beta and interleukin-10. In the present study, we examined the association of Tregs with Mycoplasma bovis infection, in which immunosuppression is frequently observed. Compared with uninfected cattle, the percentage of Tregs, CD4(+)CD25(high)Foxp3(+) T cells, was increased in M. bovis-infected cattle. Additionally, the plasma of M. bovis-infected cattle contained the high concentrations of TGF-beta 1, and M. bovis infection induced TGF-beta 1 production from bovine immune cells in in vitro cultures. Finally, we analyzed the immunosuppressive effects of TGF-beta 1 on bovine immune cells. Treatment with TGF-beta 1 significantly decreased the expression of CD69, an activation marker, in T cells, and Th1 cytokine production in vitro. These results suggest that the increase in Tregs and TGF-beta 1 secretion could be one of the immunosuppressive mechanisms and that lead to increased susceptibility to other infections in terms of exacerbation of disease during M. bovis infection.
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