期刊
PLANTS-BASEL
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/plants10010063
关键词
Curcuma; inflammation; pro-inflammatory cytokines; anti-inflammatory agents; pharmacology
Plants from the Curcuma genus are extensively used in traditional medicine for their anti-inflammatory properties, with active constituents acting on various targets in the inflammatory pathway. Both preclinical and clinical studies have shown the effectiveness of Curcuma species in reducing inflammation, providing a basis for further research in developing new anti-inflammatory agents.
The Curcuma genus has been extensively used for therapeutic purposes in traditional or folk medicine worldwide, including for its anti-inflammatory activity. Curcuma spp.'s active constituents, such as alkaloids, flavonoids, and terpenoids, can act on various targets in the signaling pathway, restrain pro-inflammatory enzymes, lower the production of inflammatory cytokines and chemokines, and reduce oxidative stress, which subsequently suppresses inflammatory processes. Preclinical and clinical studies have reported the predominant anti-inflammatory activity of several Curcuma species. This review provides an overview of the anti-inflammatory effects of different extracts, preparations, and bioactive components in this genus. This analysis may provide a scientific basis for developing new and alternative methods for the isolation of a single entity from this genus to attenuate inflammatory conditions. The Curcuma genus is waiting for researchers interested in developing safe and efficient anti-inflammatory agents for further investigation.
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