期刊
ANTIBIOTICS-BASEL
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10010085
关键词
multidrug-resistant bacteria; nosocomial infection; plant extract; grapefruit seed extract; antibacterial activity
资金
- National Research Foundation of Korea [2019R1C1C1002490]
- Ministry of Science and ICT, South Korea [2020R1A2C1005867]
- Global Research Development Center [2018K1A4A3A01064257]
- Priority Research Center [2019R1A6A1A11034536]
- University Innovation Support Program
- National Research Foundation of Korea [2019R1C1C1002490] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study aimed to identify new substances targeting MDR bacteria, with grapefruit seed extract (GSE) showing promising antibacterial effects. GSE was effective against MRSA and VRSA, even at low concentrations, making it a potential natural substance for preventing or reducing nosocomial infections.
Multidrug-resistant (MDR) bacteria are increasing due to the abuse and misuse of antibiotics, and nosocomial infections by MDR bacteria are also increasing. The aim of this study was to identify new substances that can target MDR bacteria among 12 plant extracts that are known to have antibacterial effects. The experiments were performed by the disk diffusion test and microdilution minimum inhibitory concentration (MIC) test, as described by the Clinical and Laboratory Standards Institute (CLSI). By screening against methicillin-sensitive Staphylococcus aureus (MSSA), grapefruit seed extract (GSE) was selected from 12 plant extracts for subsequent experiments. GSE showed antibacterial effects against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) in the disk diffusion test. Even at the lowest concentration, GSE showed antibacterial activity in the microdilution MIC test. As a result, we can conclude that GSE is a naturally derived antibacterial substance that exhibits a favorable antibacterial effect even at a very low concentration, so it is a good candidate for a natural substance that can be used to prevent or reduce nosocomial infections as coating for materials used in medical contexts or by mixing a small amount with other materials.
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