期刊
ANTIBIOTICS-BASEL
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10010071
关键词
anaerobic infection; cholecystitis; cholangitis; biliary tract infection
资金
- Open Access Publishing Fund of the University of Tuebingen
The study found that anaerobic bacteria are more common in patients with hepatic abscesses and gallbladder perforation, especially in the elderly with more comorbidities. Despite this, the overall outcomes for all patients were favorable and there was a low resistance rate to commonly used antibiotics.
(1) Background: Cholecystitis and cholangitis are among the most common diseases treated by general surgery. Gallstones lead to inflammation and bacterial infection of the biliary tract. Biliary infections can lead to live threatening bacteremia and liver abscesses. The true role of anaerobes remains unclear. (2) Methods: We retrospectively analyzed bacterial cultures from biliary samples obtained from bile ducts and gallbladders at our tertiary care center. Patient characteristics and clinical outcomes were analyzed. (3) Results: In our database of 1719 patients, 365 patients had microbial testing, of which 42 grew anaerobic bacteria. Anaerobes were more frequently cultured in patients with hepatic abscesses and gallbladder perforation. These patients were older and had more comorbidities than the control group. The overall outcomes of all patients were favorable and the resistance rate to commonly used antibiotics remained low. (4) Conclusions: Anaerobes in biliary tract infections appear to be underdiagnosed and more prevalent in the elderly with advanced disease. Due to low antibiotic resistance, the combination of source control and adjunct anti-infective treatment leads to favorable outcomes.
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