期刊
ANTIBIOTICS-BASEL
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics10020119
关键词
copper nanoparticle; SPION; synergistic bioactivity; hyperthermia; ion release
资金
- European Union's Horizon 2020 research and innovation program under theMarie Sklodowska-Curie [813439]
The study presents a new generation of antimicrobial magnetic nanomaterials, consisting of superparamagnetic iron oxide NPs electrodecorated with antimicrobial copper NPs, allowing for modulation of the release of bioactive species through the application of a magnetic field.
The urgency for the availability of new antibacterial/disinfectant agents has become a worldwide priority. At the same time, along with the extensive use of other metal nanoparticles (NPs), the investigation of magnetic NPs (MNPs) in antibacterial studies has turned out to be an increasingly attractive research field. In this context, we present the preparation and characterization of superparamagnetic iron oxide NPs, electrodecorated with antimicrobial copper NPs, able to modulate the release of bioactive species not only by the NP's stabilizer, but also through the application of a suitable magnetic field. Antimicrobial synergistic CuNPs stabilized by benzalkonium chloride have been used in the current study. We demonstrate the successful preparation of Cu@Fe3O4 MNPs composites through morphological and spectroscopic results. Additionally, an extensive magnetic characterization is reported, along with hyperthermia-induced copper ionic release. On the basis of our results, we propose a new generation of antimicrobial magnetic nanomaterials, whose bioactivity can be also tuned by the application of a magnetic field.
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