Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis

Radiation-induced pulmonary fibrosis is a common severe long-time complication of radiation therapy for tumors of the thorax. Current therapeutic options used in the clinic include only supportive managements strategies, such as anti-inflammatory treatment using steroids, their efficacy, however, is far from being satisfactory. Recent studies have demonstrated that the development of lung fibrosis is a dynamic and complex process, involving the release of reactive oxygen species, activation of Toll-like receptors, recruitment of inflammatory cells, excessive production of nitric oxide and production of collagen by activated myofibroblasts. In this review we summarized the current state of knowledge on the pathophysiological processes leading to the development of lung fibrosis and we also discussed the possible treatment options.

Automated summary

Radiation-induced pulmonary fibrosis is a common complication of thoracic tumor radiation therapy, with current therapeutic options being limited to supportive measures like steroids but with unsatisfactory efficacy. Recent studies have shown that lung fibrosis development is a dynamic and complex process involving various cellular and molecular interactions.