期刊
METABOLITES
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/metabo10120485
关键词
beta-cell; macrophage; islet; cytokine; diabetes
资金
- Beatson Foundation [2019-003]
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 Diabetes. Macrophages play an integral role in the maintenance or destruction of pancreatic beta-cells. The effect of the macrophage beta-cell interaction is dependent on the activation state of the macrophage. Macrophages can be activated across a spectrum, from pro-inflammatory to anti-inflammatory and tissue remodeling. The factors secreted by these differentially activated macrophages and their effect on beta-cells define the effect on functional beta-cell mass. In this review, the spectrum of macrophage activation is discussed, as are the positive and negative effects on beta-cell survival, expansion, and function as well as the defined factors released from macrophages that impinge on functional beta-cell mass.
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