期刊
PATHOGENS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10020089
关键词
Cryptosporidium felis; 60-kDa glycoprotein; subtypes; zoonotic transmission
类别
资金
- Guangdong Major Project of Basic and Applied Basic Research [2020B0301030007]
- National Natural Science Foundation of China [U1901208, 31820103014]
- 111 Project [D20008]
- Innovation Team Project of Guangdong University [2019KCXTD001]
The study investigated the genetic diversity of C. felis in cats in China and found 20 C. felis isolates with high genetic diversity, including 13 novel subtypes and 2 known subtypes of the XIXa subtype family. Some subtypes were shared between humans and cats, suggesting potential cross-species transmission of C. felis.
Cryptosporidium felis is an important cause of feline and human cryptosporidiosis. However, the transmission of this pathogen between humans and cats remains controversial, partially due to a lack of genetic characterization of isolates from cats. The present study was conducted to examine the genetic diversity of C. felis in cats in China and to assess their potential zoonotic transmission. A newly developed subtyping tool based on a sequence analysis of the 60-kDa glycoprotein (gp60) gene was employed to identify the subtypes of 30 cat-derived C. felis isolates from Guangdong and Shanghai. Altogether, 20 C. felis isolates were successfully subtyped. The results of the sequence alignment showed a high genetic diversity, with 13 novel subtypes and 2 known subtypes of the XIXa subtype family being identified. The known subtypes were previously detected in humans, while some of the subtypes formed well-supported subclusters with human-derived subtypes from other countries in a phylogenetic analysis of the gp60 sequences. The results of this study confirmed the high genetic diversity of the XIXa subtype family of C. felis. The common occurrence of this subtype family in both humans and cats suggests that there could be cross-species transmission of C. felis.
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