期刊
PATHOGENS
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10010074
关键词
non-typhoidal Salmonella; virulence factor; pathogenicity; clinical isolates
类别
资金
- Taiwan Centers for Disease Control [MOHW103CDC-C-114-000802, MOHW104-CDC-C-114-113701, MOHW105-CDC-C-114-123302]
The study investigated virulence traits and molecular diversity of clinical isolates of Salmonella, revealing varying virulence properties among different serotypes depending on the environment. The susceptibility of the tested strains to antibiotics varied, with some showing resistance to multiple drugs, emphasizing the need for continuous monitoring and updating of microbiological and molecular reports.
Non-typhoidal and Typhoidal Salmonella are bacterial pathogens source of worldwide and major disease burden. Virulent determinants of specific serovars belonging to non-typhoidal Salmonella have been extensively studied in different models, yet the pathogenesis of this group of bacteria and the development of clinical symptoms globally remains underexplored. Herein, we implemented microbiological and molecular procedures to investigate isolate virulence traits and molecular diversity, likely in association with disease severity. Our results show that selected clinical isolates from a tertiary referring hospital, depending on the richness of the environment and isolate serotypes, exhibited different, and sometimes controversial, virulence properties. The tested strains were susceptible to Ceftriaxone (90%) with decreasing reactivity to Trimethoprim-Sulfamethoxazole (72%), Chloramphenicol (64%), Ampicillin (48%), Gentamicin (44%), and Ciprofloxacin (2%). Disc susceptibility results partially correlated with minimum inhibitory concentration (MIC); however, special attention must be given to antimicrobial treatment, as a rise in multi-resistant isolates to Trimethoprim-Sulfamethoxazole (2/38 mu g/mL), Minocycline (8 mu g/mL) and Ampicillin (16 mu g/mL) has been noticed, with two isolates resistant to Ceftazidime (16 mu g/mL). By comparison to previous molecular epidemiology studies, the variation in the gene profiles of endemic pathogens supports the need for continuous and up-to-date microbiological and molecular reports.
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