期刊
FRONTIERS IN SYSTEMS NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnsys.2020.599781
关键词
general anesthesia; burst suppression; widefield calcium imaging; thalamocortical interactions; traveling wave; slow oscillations
资金
- National Key Research and Development Program of China [2017YFC0107200]
- National Natural Science Foundation of China [81571264, 81971205, 81771396]
- Jilin Province Science and Technology Development Program [20180414059GH, 20191102001YY]
- First Hospital of Jilin University [JDYYZH-1902006]
Isoflurane-induced burst suppression is not a globally synchronous rhythm, but a series of locally asynchronous cortical events facilitated by thalamic projection, unfolding as rapid, bilaterally asynchronous propagating waves.
Background: Inhalational anesthetic-induced burst suppression (BS) is classically considered a bilaterally synchronous rhythm. However, local asynchrony has been predicted in theoretical studies and reported in patients with pre-existing focal pathology. Method: We used high-speed widefield calcium imaging to study the spatiotemporal dynamics of isoflurane-induced BS in rats. Results: We found that isoflurane-induced BS is not a globally synchronous rhythm. In the neocortex, neural activity first emerged in a spatially shifting, variably localized focus. Subsequent propagation across the whole cortex was rapid, typically within <100 milliseconds, giving the superficial resemblance to global synchrony. Neural activity remained locally asynchronous during the bursts, forming complex recurrent propagating waves. Despite propagation variability, spatial sequences of burst propagation were largely preserved between the hemispheres, and neural activity was highly correlated between the homotopic areas. The critical role of the thalamus in cortical burst initiation was demonstrated by using unilateral thalamic tetrodotoxin injection. Conclusion: The classical impression that anesthetics-induced BS is a state of global brain synchrony is inaccurate. Bursts are a series of shifting local cortical events facilitated by thalamic projection that unfold as rapid, bilaterally asynchronous propagating waves.
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