期刊
ANTIOXIDANTS
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/antiox10010046
关键词
oxidative stress; ROS; neurodegenerative diseases; red grape polyphenol extract; white grape seed polyphenol extract; MecobalActive(®); Olews(®)
资金
- Spanish Ministry of Science, Innovation, and Universities [RTC-2017-6424-1]
- European Regional Development Fund (FEDER)
The study showed that certain bioactive natural supplements may have important protective properties against oxidative stress in the brain, including reducing reactive oxygen species levels, decreasing caspase-3 activity, and increasing the activity of antioxidant enzymes with preventive treatment.
Neurodegenerative diseases pose a major health problem for developed countries, and stress has been identified as one of the main risk factors in the development of these disorders. Here, we have examined the protective properties against oxidative stress of several bioactive natural food supplements. We found that MecobalActive(R), Olews(R), and red and white grape seed polyphenol extracts may have a neuroprotective effect in vitro, both in the SH-SY 5Y cell line and in hippocampal neuron cultures, mainly by reducing reactive oxygen species levels and decreasing caspase-3 activity. In vivo, we demonstrated that oral administration of the supplements reduces the expression of genes involved in inflammation and oxidation mechanisms, whereas it increments the expression of genes related to protection against oxidative stress. Furthermore, we found that preventive treatment with these natural extracts increases the activity of antioxidant enzymes and prevents lipid peroxidation in the brain of stressed mice. Thus, our results indicate that some natural bioactive supplements may have important protective properties against oxidative stress processes occurring in the brain.
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