期刊
ANTIOXIDANTS
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/antiox9121191
关键词
heme oxygenase-1; antioxidant; anti-inflammatory compound; foodstuff; medicinal herbs
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [NRF-2020R1A2C1004131, 2019R1F1A1051041]
- Gyeongnam Technopark grant - Gyeongsangnam-do, Korea
- National Research Foundation of Korea [2019R1F1A1051041] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Heme oxygenase-1 (HO-1) is an inducible antioxidant enzyme that catalyzes heme group degradation. Decreased level of HO-1 is correlated with disease progression, and HO-1 induction suppresses development of metabolic and neurological disorders. Natural compounds with antioxidant activities have emerged as a rich source of HO-1 inducers with marginal toxicity. Here we discuss the therapeutic role of HO-1 in obesity, hypertension, atherosclerosis, Parkinson's disease and hepatic fibrosis, and present important signaling pathway components that lead to HO-1 expression. We provide an updated, comprehensive list of natural HO-1 inducers in foodstuff and medicinal herbs categorized by their chemical structures. Based on the continued research in HO-1 signaling pathways and rapid development of their natural inducers, HO-1 may serve as a preventive and therapeutic target for metabolic and neurological disorders.
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