期刊
ANTIOXIDANTS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox10020154
关键词
eryptosis; metabolic syndrome; diabetes; dyslipidemia; hypertension; obesity; atherosclerosis; vascular damage; oxidative stress; endothelial dysfunction
Eryptosis is a programmed cell death process that, when dysregulated, can lead to endothelial dysfunction and cardiovascular complications in metabolic syndrome. This review focuses on the involvement and mechanisms of eryptosis in metabolic syndrome, as well as the clinical evidence supporting its role in endothelial dysfunction and associated cardiovascular complications.
Eryptosis is a coordinated, programmed cell death culminating with the disposal of cells without disruption of the cell membrane and the release of endocellular oxidative and pro-inflammatory milieu. While providing a convenient form of death for erythrocytes, dysregulated eryptosis may result in a series of detrimental and harmful pathological consequences highly related to the endothelial dysfunction (ED). Metabolic syndrome (MetS) is described as a cluster of cardiometabolic factors (hyperglycemia, dyslipidemia, hypertension and obesity) that increases the risk of cardiovascular complications such as those related to diabetes and atherosclerosis. In the light of the crucial role exerted by the eryptotic process in the ED, the focus of the present review is to report and discuss the involvement of eryptosis within MetS, where vascular complications are utterly relevant. Current knowledge on the mechanisms leading to eryptosis in MetS-related conditions (hyperglycemia, dyslipidemia, hypertension and obesity) will be analyzed. Moreover, clinical evidence supporting or proposing a role for eryptosis in the ED, associated to MetS cardiovascular complications, will be discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据