期刊
ANTIOXIDANTS
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/antiox10010128
关键词
reactive oxygen species; antioxidants; detection methods; harmful and beneficial effects
资金
- AIMST University, Malaysia
Evidence suggests that reactive oxygen species (ROS) play complex roles in cancer, with both beneficial and harmful effects, depending on concentration. Further research is needed to understand the relationship between ROS, antioxidants, and cancer, and to develop more accurate methods for ROS detection.
Evidence suggests that reactive oxygen species (ROS) mediate tissue homeostasis, cellular signaling, differentiation, and survival. ROS and antioxidants exert both beneficial and harmful effects on cancer. ROS at different concentrations exhibit different functions. This creates necessity to understand the relation between ROS, antioxidants, and cancer, and methods for detection of ROS. This review highlights various sources and types of ROS, their tumorigenic and tumor prevention effects; types of antioxidants, their tumorigenic and tumor prevention effects; and abnormal ROS detoxification in cancer; and methods to measure ROS. We conclude that improving genetic screening methods and bringing higher clarity in determination of enzymatic pathways and scale-up in cancer models profiling, using omics technology, would support in-depth understanding of antioxidant pathways and ROS complexities. Although numerous methods for ROS detection are developing very rapidly, yet further modifications are required to minimize the limitations associated with currently available methods.
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