The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration

The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly compensate for myocardial cell loss after myocardial injury. Studies have shown that exercise has a regulatory role in the activation and promotion of regeneration of healthy and injured adult cardiomyocytes. However, current research on the effects of aerobic exercise in myocardial regeneration is not comprehensive. This review discusses the relationships between aerobic exercise and the regeneration of cardiomyocytes with respect to complex molecular and cellular mechanisms, paracrine factors, transcriptional factors, signaling pathways, and microRNAs that induce cardiac regeneration. The topics discussed herein provide a knowledge base for physical activity-induced cardiomyocyte regeneration, in which exercise enhances overall heart function and improves the efficacy of cardiac rehabilitation.

Automated summary

Aerobic exercise plays a positive role in heart health and regeneration, although current research on its effects is not comprehensive. Complex molecular and cellular mechanisms, along with paracrine factors, transcriptional factors, signaling pathways, and microRNAs, contribute to cardiomyocyte regeneration induced by physical activity.