4.7 Article

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2020.619858

关键词

pulsatile fluid flow-induced loading; intracranial aneurysms; polyethylene glycol dimethacrylate; hydrogels; fatigue; erosion

资金

  1. Swiss National Science Foundation (SNF Sinergia grant) [CRSII5_170992]
  2. Swiss National Science Foundation (SNF) [CRSII5_170992] Funding Source: Swiss National Science Foundation (SNF)

向作者/读者索取更多资源

Hydrogels are emerging as a promising intracranial aneurysm embolic agent for their ability to be injected in liquid phase and solidify in situ, providing better filling of an aneurysm sac compared to solid implants. Photopolymerizable poly(ethylene glycol) dimethacrylate (PEGDMA) hydrogels have been demonstrated to be feasible for aneurysm application in vitro, with fine-tuning to match the elastic modulus and compliance of aneurysmal tissue. In a fatigue test under physiological pulsatile flow, these hydrogels showed minimal surface erosion defects and no significant weight loss, indicating their potential for in vivo implant studies.
An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants such as those used in coil embolization. Recently, the feasibility to implement photopolymerizable poly(ethylene glycol) dimethacrylate (PEGDMA) hydrogels in vitro has been demonstrated for aneurysm application. Nonetheless, the physical and mechanical properties of such hydrogels require further characterization to evaluate their long-term integrity and stability to avoid implant compaction and aneurysm recurrence over time. To that end, molecular weight and polymer content of the hydrogels were tuned to match the elastic modulus and compliance of aneurysmal tissue while minimizing the swelling volume and pressure. The hydrogel precursor was injected and photopolymerized in an in vitro aneurysm model, designed by casting polydimethylsiloxane (PDMS) around 3D printed water-soluble sacrificial molds. The hydrogels were then exposed to a fatigue test under physiological pulsatile flow, inducing a combination of circumferential and shear stresses. The hydrogels withstood 5.5 million cycles and no significant weight loss of the implant was observed nor did the polymerized hydrogel protrude or migrate into the parent artery. Slight surface erosion defects of 2-10 mu m in depth were observed after loading compared to 2 mu m maximum for non-loaded hydrogels. These results show that our fine-tuned photopolymerized hydrogel is expected to withstand the physiological conditions of an in vivo implant study.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据