期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.621644
关键词
heart; extracellular matrix; cardiac ontogeny; cardiovascular diseases; decellularization; fibrosis; regeneration
资金
- European Regional Development Fund (ERDF) through COMPETE 2020, Portugal 2020
- FCT (Fundacao para a Ciencia e Tecnologia) [POCI-010145-FEDER-030985]
- FCT/Ministerio da Ciencia, Tecnologia e Inovacao [CEECINST/00091/2018]
- Fundação para a Ciência e a Tecnologia [CEECINST/00091/2018] Funding Source: FCT
The extracellular matrix (ECM) plays a crucial role in heart development and disease, with fibrosis being a major manifestation of many cardiovascular diseases. Effective treatments for managing fibrosis and promoting ECM repair are currently lacking. Understanding ECM composition and function is important for developing more efficient therapies for heart conditions.
The extracellular matrix (ECM) is an essential component of the heart that imparts fundamental cellular processes during organ development and homeostasis. Most cardiovascular diseases involve severe remodeling of the ECM, culminating in the formation of fibrotic tissue that is deleterious to organ function. Treatment schemes effective at managing fibrosis and promoting physiological ECM repair are not yet in reach. Of note, the composition of the cardiac ECM changes significantly in a short period after birth, concurrent with the loss of the regenerative capacity of the heart. This highlights the importance of understanding ECM composition and function headed for the development of more efficient therapies. In this review, we explore the impact of ECM alterations, throughout heart ontogeny and disease, on cardiac cells and debate available approaches to deeper insights on cell-ECM interactions, toward the design of new regenerative therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据