期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.611185
关键词
stress granules (SG); immune cells; post-transcriptional regulation; translation; mRNA; RNA-binding proteins (RBP); integrated stress response (ISR); mTOR
资金
- INSERM
- Universite de Toulouse 3
- CNRS
- Laboratoire d'Excellence TouCan
- Roche (imCORE)
- Ligue Contre Le Cancer
- Canceropole Grand SudOuest
- Fondation ARC Pour la Recherche sur le Cancer (Equipe Labellisee) [PGA1 RF20190208691]
Immune cell activation leads to transcriptional and translational programs, with stress granules playing a crucial role in controlling protein synthesis and ensuring accurate effector functions in immune cells.
Immune cell activation triggers transcriptional and translational programs eliciting cellular processes, such as differentiation or proliferation, essential for an efficient immune response. These dynamic processes require an intricate orchestration of regulatory mechanisms to control the precise spatiotemporal expression of proteins. Post-transcriptional regulation ensures the control of messenger RNA metabolism and appropriate translation. Among these post-transcriptional regulatory mechanisms, stress granules participate in the control of protein synthesis. Stress granules are ribonucleoprotein complexes that form upon stress, typically under control of the integrated stress response. Such structures assemble upon stimulation of immune cells where they control selective translational programs ensuring the establishment of accurate effector functions. In this review, we summarize the current knowledge about post-transcriptional regulation in immune cells and highlight the role of stress sensors and stress granules in such regulation.
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