Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies

Age-related macular degeneration (AMD) is a neurodegenerative disease of the aging retina, in which patients experience severe vision loss. Therapies available to patients are limited and are only effective in a sub-population of patients. Future comprehensive clinical care depends on identifying new therapeutic targets and adopting a multi-therapeutic approach. With this goal in mind, this review examines the fundamental concepts underlying the development and progression of AMD and re-evaluates the pathogenic pathways associated with the disease, focusing on the impact of injury at the cellular level, with the understanding that critical assessment of the literature may help pave the way to identifying disease-relevant targets. During this process, we elaborate on responses of AMD vulnerable cells, including photoreceptors, retinal pigment epithelial cells, microglia, and choroidal endothelial cells, based on in vitro and in vivo studies, to select stressful agents, and discuss current therapeutic developments in the field, targeting different aspects of AMD pathobiology.

Automated summary

AMD is a neurodegenerative disease of the aging retina, resulting in severe vision loss for patients. Current therapies are limited in effectiveness, and future comprehensive care requires identifying new therapeutic targets and utilizing multiple therapeutic approaches. By examining AMD development and progression, researchers aim to identify disease-related targets and advance therapeutic developments.