4.7 Review

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

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AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

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The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth

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Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway

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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

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Induction of sestrin 2 is associated with fisetin-mediated apoptosis in human head and neck cancer cell lines

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Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway

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Knockdown of sestrin2 increases pro-inflammatory reactions and ER stress in the endothelium via an AMPK dependent mechanism

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Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress

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Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

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Sestrin2 protects the myocardium against radiation-induced damage

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The apo-structure of the leucine sensor Sestrin2 is still elusive

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GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

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AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy

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Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

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Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

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The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury

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Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

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Sestrin2 Protein Positively Regulates AKT Enzyme Signaling and Survival in Human Squamous Cell Carcinoma and Melanoma Cells

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Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

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Hepatoprotective role of Sestrin2 against chronic ER stress

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Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

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CELL REPORTS (2014)

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Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle

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Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

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CELL METABOLISM (2013)

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SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

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EXPERIMENTAL GERONTOLOGY (2013)

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Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction

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TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

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Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury

Masayuki Ishihara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

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Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

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CELL METABOLISM (2012)

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CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

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FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3

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JOURNAL OF CELL SCIENCE (2012)

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Stress-Responsive Sestrins Link p53 with Redox Regulation and Mammalian Target of Rapamycin Signaling

Andrei V. Budanov

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Is Overoxidation of Peroxiredoxin Physiologically Significant?

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ANTIOXIDANTS & REDOX SIGNALING (2011)

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Rapamycin-induced glucose intolerance Hunger or starvation diabetes

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

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Sestrins at the crossroad between stress and aging

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AGING-US (2010)

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Stressin' Sestrins take an aging fight

Andrei V. Budanou et al.

EMBO MOLECULAR MEDICINE (2010)

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Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis

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Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

Jun Hee Lee et al.

SCIENCE (2010)

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Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

Hyun Ae Woo et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

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Stimulation of autophagy by the p53 target gene Sestrin2

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CELL CYCLE (2009)

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Tumor suppressors and cell metabolism: a recipe for cancer growth

Russell G. Jones et al.

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p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling

Andrei V. Budanov et al.

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The antioxidant function of the p53 tumor suppressor

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Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

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