期刊
PHOTOACOUSTICS
卷 20, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.pacs.2020.100213
关键词
Photoacoustic computed tomography; Transcranial imaging; Back-projection; Reconstruction; Acoustic aberration
类别
资金
- United States National Institutes of Health (NIH) [R01 CA186567, R35 CA220436, U01 NS099717, U01 EB029823]
- Caltech internal funds [PPF0021]
A major challenge of transcranial human brain photoacoustic computed tomography (PACT) is correcting for the acoustic aberration induced by the skull. Here, we present a modified universal back-projection (UBP) method, termed layered UBP (L-UBP), that can de-aberrate the transcranial PA signals by accommodating the skull heterogeneity into conventional UBP. In L-UBP, the acoustic medium is divided into multiple layers: the acoustic coupling fluid layer between the skull and detectors, the skull layer, and the brain tissue layer, which are assigned different acoustic properties. The transmission coefficients and wave conversion are considered at the fluid-skull and skull-tissue interfaces. Simulations of transcranial PACT using L-UBP were conducted to validate the method. Ex vivo experiments with a newly developed three-dimensional PACT system with 1-MHz center frequency demonstrated that L-UBP can substantially improve the image quality compared to conventional UBP.
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