期刊
VIRUS EVOLUTION
卷 7, 期 1, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/ve/veaa094
关键词
SARS-CoV-2; host adaptation; mink; protein structure; humoral immunity; public health
类别
Recent studies have shown multiple transmission events of SARS-CoV-2 between humans and minks on farms, resulting in viral mutations. These mutations may affect the interaction between the virus and minks as well as humans, highlighting the importance of continued monitoring and attention to this issue.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on mink farms are increasingly observed in several countries, leading to the massive culling of animals on affected farms. Recent studies showed multiple (anthropo)zoonotic transmission events between humans and mink on these farms. Mink-derived SARS-CoV-2 sequences from The Netherlands and Denmark contain multiple substitutions in the S protein receptor binding domain (RBD). Molecular modeling showed that these substitutions increase the mean binding energy, suggestive of potential adaptation of the SARS-CoV-2 S protein to the mink angiotensin-converting enzyme 2 (ACE2) receptor. These substitutions could possibly also impact human ACE2 binding affinity as well as humoral immune responses directed to the RBD region of the SARS-CoV-2 S protein in humans. We wish to highlight these observations to raise awareness and urge for the continued surveillance of mink (and other animal)-related infections.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据