期刊
GUT MICROBES
卷 13, 期 1, 页码 1-12出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2020.1863135
关键词
Serrated pathway; microbiota; colorectal cancer; neoplasia
资金
- Science and Technology Program Grant Shenzhen [JCYJ20170413161534162]
- HMRF Hong Kong [17160862]
- RGC-CRF Hong Kong [C4039-19G]
- RGC-GRF Hong Kong [14163817]
- National Natural Science Foundation of China [31871340, 81922082]
Colorectal cancer is a heterogeneous disease with different gene expression patterns, characterized by two major colorectal carcinogenesis pathways: conventional adenoma-carcinoma pathway and alternative serrated neoplasia pathway. Although serrated lesions have malignant potential and unique characteristics, they are often overlooked due to their anatomical location and histological features. Environmental factors, especially the gut microbial composition, play a crucial role in CRC pathogenesis, with potential interactions between microbiota composition and host genetic perturbations in the development of serrated lesions.
Colorectal cancer (CRC) is a heterogeneous disease with different gene expression patterns. There are two major colorectal carcinogenesis pathways: conventional adenoma-carcinoma pathway and alternative serrated neoplasia pathway. Apart from the conventional pathway that is typically initiated by characteristic APC mutation and chromosomal instability, the serrated neoplasia pathway is mainly characterized by mutations of BRAF or KRAS, microsatellite instability (MSI), and CpG island methylator phenotype (CIMP). Despite the malignant potential of serrated lesions, they can be easily overlooked during endoscopy screening and even in pathological assessment due to its anatomical location, morphology, and histological features. It has been shown that environmental factors especially the gut microbial composition play a key role in CRC pathogenesis. Thus, the preferential localization of serrated lesions in specific intestine areas suggest that niche-specific microbiota composition might intertwined with host genetic perturbations during the development of serrated lesions. Although serrated lesions and conventional adenomas are biologically different, most studies have focused on conventional adenomas, while the pathophysiology and role of microorganisms in the development of serrated lesions remain elusive. In this review, we discuss on the role of gut microbiota in the serrated neoplasia pathway of colorectal carcinogenesis and its specific clinical and molecular features, and summarize the potential mechanisms involved.
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