期刊
APPLIED MATERIALS TODAY
卷 22, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apmt.2020.100888
关键词
Copper; Zinc; Immunomodulation; Antimicrobial; Osteogenesis
资金
- National Natural Science Foundation of China [81974324, 81772364, 81772309, 81671830]
- National Key Research and Development Program of China [2016YFC1100201]
- Science and Technology Commission of Shanghai Municipality [19441902300, 19411962600]
A sequential immunomodulatory strategy using Cu-Zn bi-layer nanofibrous membranes was proposed to address implant-related infections and implant osseointegration disorders, based on the immunological characteristics of these complications. The biomaterial exhibited controlled release of Cu2+ and Zn2+, regulating macrophage phenotype shift and demonstrating anti-infection and osteogenic abilities in vitro and in vivo.
Implant-related infections (IRIs) and implant osseointegration disorders are the most common and catastrophic complications after total joint arthroplasty (TJA). Macrophages play a vital role in the development of these complications. Herein, tailored to the immunological characteristics of IRIs and implant osseointegration disorders, we proposed a sequential immunomodulatory strategy to cope with the complications, using Cu-Zn bi-layer nanofibrous membranes synthesized via a facile electrospinning process and a hot-pressed method. It was found that Cu-Zn bi-layer nanofibrous membranes exhibited a desirable controlled release of Cu2+ and Zn2+, and could sequentially regulate macrophage phenotype shift from M1 to M2 through alternately activating the MAPK and mTOR signaling pathways. Moreover, the dual-temporal bidirectional immunomodulatory effect endowed the Cu-Zn bi-layer nanofibrous membranes excellent anti-infection and osteogenic abilities in vitro and in vivo. To our knowledge, this is the first dual-temporal bidirectional immunomodulatory biomaterial specifically designed for the immune requirements of IRIs and implant osseointegration disorders. This is a meaningful attempt, which may pave a new way for exploring novel immunomodulatory biomaterials to solve the clinical challenges. (C) 2020 Elsevier Ltd. All rights reserved.
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