期刊
SCIENCE IMMUNOLOGY
卷 5, 期 54, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.abf3698
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资金
- Citadel and Citadel Securities
- Guy Foundation
- Kusuma Trust
- Jagclif Charitable Trust
- Barts Charity
- UCLH Charity
- Barts Health NHS Trust
- Royal Free NHS Foundation Trust
- Queen Mary University London
- MRC [MR/S019553/1, MR/R02622X/1, MR/V036939/1]
- NIHR Imperial Biomedical Research Centre (BRC):ITMAT
- Cystic Fibrosis Trust SRC [2019SRC015]
- Horizon 2020 Marie Sklodowska-Curie Innovative Training Network (ITN) European Training Network [860325]
- Wellcome Trust Investigator Award [214191/Z/18/Z]
- CRUK Immunology grant [26603]
- Medical Research Foundation fellowship [044-0001]
- Rosetrees Trust
- John Black Charitable Foundation
- Medical College of St Bartholomew's Hospital Trust
- University College London Hospitals (UCLH)
- Barts NIHR Biomedical Research Centres and through the British Heart Foundation (BHF) Accelerator Award [AA/18/6/34223]
- BHF Intermediate Research Fellowship [FS/19/35/34374]
- Wellcome Trust [207511/Z/17/Z]
- NIHR Biomedical Research Funding to UCL
- GW Pharmaceuticals
- Wellcome Trust [214191/Z/18/Z] Funding Source: Wellcome Trust
- MRC [MR/V036939/1, MR/S019553/1, MR/V028448/1, MR/R02622X/1] Funding Source: UKRI
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV2 infection.
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