期刊
ELECTROANALYSIS
卷 28, 期 11, 页码 2760-2770出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201600241
关键词
4-aminobiphenyl; DNA; hanging mercury drop electrode; interaction; 4-nitrobiphenyl; voltammetry
资金
- Grant Agency of the Czech Republic [P206/12/G151]
Differential pulse voltammetry, cyclic voltammetry, alternating current voltammetry, and chronocoulometry at a hanging mercury drop electrode (HMDE) and DNA modified HMDE were used for the study of the interaction of 4-nitrobiphenyl (4-NBP) with double-stranded DNA and for the detection of DNA damage caused by its interaction with 4-NBP. Moreover, the interaction of DNA with intermediates of the 4-NBP reduction and with 4-aminobiphenyl, a metabolite of 4-NBP, was investigated. The mechanism of the electrochemical reduction of 4-NBP was investigated using CV, too. It was found that the reduction of 4-NBP is controlled by both diffusion and adsorption. The rate constant of the reduction and the diffusion coefficient were calculated as well.
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