Reduction of Anthelmintic Drug (Methyl [1]carbamate-albendazole) on Gold Electrodes in Aprotic Solvent: Analysis of Chromatographic Reduction Products

Albendazole (ABZ) is a widely used anthelmintic drug for the treatment of parasitic worms and other diseases. The bulk electrolysis reduction reaction of albendazole (ABZ) was carried out in ammonium bromide-acetonitrile solution under stirring conditions. The reduction of albendazole at gold electrode gave three non-reversible waves. The average value of the electron transfer coefficient (n) was found to be 0.505. The measured diffusion coefficient (D) had a value of 0.143x10(-8)cm(2)s(-1). The bulk electrochemical reduction of ABZ products were characterized using liquid chromatography-mass spectroscopy. Three cyclic voltammetry reduction waves were observed using a gold electrode and three chromatographic peaks were observed using liquid chromatography- Mass spectrometry. The observed results suggested that the second and third reduction steps occurred at the sulfur functional group of albendazole.