期刊
ELECTROANALYSIS
卷 28, 期 9, 页码 2222-2227出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201600042
关键词
Paracetamol; Molecularly imprinted polymers; Electropolymerization; Tyrosinase; Esterase; Phenacetin
资金
- Deutsche Forschungsgemeinschaft (DFG) within the framework of the German Excellence Initiative [EXC 314]
- BMBF in TERA-Sens [93719903]
A new electrochemical MIP sensor for the most frequently used drug paracetamol (PAR) was prepared by electropolymerization of mixtures containing the template molecule and the functional monomers ophenylenediamine, resorcinol and aniline. The imprinting factor of 12 reflects the effective target binding to the MIP as compared with the non-imprinted electropolymer. Combination of the MIP with a nonspecific esterase allows the measurement of phenacetin - another analgesic drug. In the second approach the PAR containing sample solution was pretreated with tyrosinase in order to prevent electrochemical interferences by ascorbic acid and uric acid. Interference-free indication at a very low electrode potential without fouling of the electrode surface was achieved with the o-phenylenediamine: resorcinol-based MIP.
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