An Ethical Assessment Tool (ETHAS) to Evaluate the Application of Assisted Reproductive Technologies in Mammals' Conservation: The Case of the Northern White Rhinoceros (Ceratotherium simum cottoni)

Simple Summary Applying assisted reproductive technologies (ARTs) to the conservation of endangered species may be the only way to save them from extinction. However, ART application can raise relevant ethical issues and could benefit from a comprehensive ethical assessment. Unfortunately, there is a lack of attention to the topic in the scientific literature and, to our knowledge, there is no tool for the ethical assessment of ARTs in the context of conservation that has been described. In the present paper, we show the effects of applying a dedicated ethical self-assessment tool, the Ethical Assessment Tool (ETHAS), to ovum pick-up and in vitro fertilization procedures performed within the BioRescue project. The BioRescue project is an international enterprise using ARTs to save the northern white rhinoceros from extinction. The situation of the northern white rhinoceros is particularly critical as there are only two individuals of this subspecies still alive and they are both infertile females. The application of the ETHAS to the procedures contributed to the overall acceptability of the project and improved communication among the project's partners. In turn, the tool itself was also refined through an iterative consultation process between experts (both ethicists and scientists) and stakeholders. Assisted reproductive technologies (ARTs) can make a difference in biodiversity conservation. Their application, however, can create risks and raise ethical issues that need addressing. Unfortunately, there is a lack of attention to the topic in the scientific literature and, to our knowledge, there is no tool for the ethical assessment of ARTs in the context of conservation that has been described. This paper reports the first applications of the Ethical Assessment Tool (ETHAS) to trans-rectal ovum pick-up (OPU) and in vitro fertilization (IVF) procedures used in a northern white rhinoceros (Ceratotherium simum cottoni) conservation project. The ETHAS consists of two checklists, the Ethical Evaluation Sheet and the Ethical Risk Assessment, and is specifically customized for each ART procedure. It provides an integrated, multilevel and standardized self-assessment of the procedure under scrutiny, generating an ethical acceptability ranking (totally, partially, not acceptable) and a risk rank (low, medium, high), and, hence, allows for implementing measures to address or manage issues beforehand. The application of the ETHAS to the procedures performed on the northern white rhinoceros was effective in ensuring a high standard of procedures, contributing to the acceptability and improved communication among the project's partners. In turn, the tool itself was also refined through an iterative consultation process between experts and stakeholders.

Automated summary

This paper discusses the application of an ethical self-assessment tool, ETHAS, to ovum pick-up and in vitro fertilization procedures used in a conservation project for the endangered northern white rhinoceros, showing its effectiveness in ensuring procedure standards and improving communication among partners.