Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

Automated summary

This study found that infliximab had dramatic responses in cases of tuberculous meningitis with severe paradoxical reactions, despite initial treatment with high-dose steroids. However, delayed initiation of infliximab as a last resort may have adversely affected patient outcomes.