期刊
PHARMACEUTICS
卷 13, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13010033
关键词
adenosine; solid lipid nanoparticles; elastic artificial skin; anti-wrinkle; skin permeation
资金
- Technology Innovation Program - Ministry of Trade, Industry & Energy (MOTIE, Korea) [10077593]
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2015R1A5A1008958]
- Chung-Ang University
- Korea Evaluation Institute of Industrial Technology (KEIT) [10077593] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, an elastic artificial skin for treating wrinkles with poor skin permeation of adenosine was developed, along with a lipid-based nano-carrier to enhance the skin permeation of adenosine. The results showed that the elastic artificial skin incorporated with adenosine-loaded solid lipid nanoparticles exhibited better drug release characteristics.
Adenosine (AD), which is used for treating wrinkles, exhibits poor skin permeation. The aim of the present study was to develop a cross-linked silicone-based cellulose elastomer as an elastic artificial skin for the treatment of skin wrinkles, a biocompatible lipid-based nano-carrier for enhancing the skin permeation of AD, and a formulation consisting of the lipid-based carrier incorporated in the elastic artificial skin. AD-loaded solid lipid nanoparticles (SLNs) were prepared using a double-emulsion method. Particle characteristics and mechanical properties of SLNs and elastic artificial skin, respectively, were assessed. Skin permeation was evaluated using SkinEthic RHE tissue, a reconstructed human epidermis model. The mean particle size and zeta potential for SLNs ranged from 123.57 to 248.90 nm and -13.23 to -41.23 mV, respectively. The components of neither SLNs nor the elastic artificial skin were cytotoxic, according to cell- and tissue-viability assays and EU classification. SLNs and the elastic artificial skin exhibited sustained drug release for 48 h. The amount of AD released from SLNs and elastic artificial skin was approximately 10 times and 5 times higher, respectively, than that from AD solution. Therefore, elastic artificial skin incorporated with AD-loaded SLNs may serve as a promising topical delivery system for cosmeceutical treatment of skin wrinkles.
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