期刊
PHARMACEUTICS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13020155
关键词
nanomaterials; protein delivery; anticancer therapy; cancer treatment; nanotechnology
资金
- NIH [7R01AR072027, 7R03AR069383]
- NSF Career Award [1905785]
- University of Connecticut
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1905785] Funding Source: National Science Foundation
Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles, have been extensively studied for drug delivery, with a focus on utilizing proteins for therapeutic purposes in anticancer treatments. Protein therapeutics have shown promising potential in various applications, including genetic defect correction, nanocarrier functions, and gene editing for anticancer effects.
Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to recently developed biologics, such as proteins, peptides, and nucleic acids. Among them, proteins have shown a series of advantages and potential in various therapeutic applications, such as introducing therapeutic proteins due to genetic defects, or used as nanocarriers for anticancer agents to decelerate tumor growth or control metastasis. This review discusses the existing nanoparticle delivery systems, introducing design strategies, advantages of using each system, and possible limitations. Moreover, we will examine the intracellular delivery of different protein therapeutics, such as antibodies, antigens, and gene editing proteins into the host cells to achieve anticancer effects and cancer vaccines. Finally, we explore the current applications of protein delivery in anticancer treatments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据