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JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)
Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids
Kimberley A. Beaumont et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)
A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting
Eric B. Berens et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)
Three-Dimensional (3D) Tumor Spheroid Invasion Assay
Maria Vinci et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)
Spherical Cancer Models in Tumor Biology
Louis-Bastien Weiswald et al.
NEOPLASIA (2015)
3D Cell Culture Systems: Advantages and Applications
Maddaly Ravi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing
Xue Gong et al.
PLOS ONE (2015)
A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio
David Robert Grimes et al.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS (2015)
Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems
Niravkumar R. Patel et al.
THERAPEUTIC DELIVERY (2015)
Label-Free Single Cell Kinetics of the Invasion of Spheroidal Colon Cancer Cells through 3D Matrigel
Nicole K. Febles et al.
ANALYTICAL CHEMISTRY (2014)
Optimization of Liquid Overlay Technique to Formulate Heterogenic 3D Co-Cultures Models
Elisabete C. Costa et al.
BIOTECHNOLOGY AND BIOENGINEERING (2014)
The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors
Can Sarisozen et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)
Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism
Jianqun Liao et al.
PLOS ONE (2014)
Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro - Implication for Drug Development
Jason E. Ekert et al.
PLOS ONE (2014)
Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres
Delyan P. Ivanov et al.
PLOS ONE (2014)
Effect of Vascular Formed Endothelial Cell Network on the Invasive Capacity of Melanoma Using the In Vitro 3D Co-Culture Patterning Model
Shuhei Yamamoto et al.
PLOS ONE (2014)
Three-Dimensional In Vitro Co-Culture Model of Breast Tumor using Magnetic Levitation
Hamsa Jaganathan et al.
SCIENTIFIC REPORTS (2014)
Viability Assays for Cells in Culture
Jessica M. Posimo et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2014)
Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM
Stephen J. Florczyk et al.
BIOMATERIALS (2013)
Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles
Xin Wang et al.
BIOMATERIALS (2013)
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing
Paola Longati et al.
BMC CANCER (2013)
Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
Uma Prabhakar et al.
CANCER RESEARCH (2013)
Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles
Mark J. Ernsting et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Microenvironmental regulation of tumor progression and metastasis
Daniela F. Quail et al.
NATURE MEDICINE (2013)
In vitro irradiation system for radiobiological experiments
Anna Tesei et al.
RADIATION ONCOLOGY (2013)
Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro
Kevin Alessandri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Micropatterned co-culture of hepatocyte spheroids layered on non-parenchymal cells to understand heterotypic cellular interactions
Hidenori Otsuka et al.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2013)
Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery
Ying Wang et al.
BIOMATERIALS SCIENCE (2013)
The Use of Porous Scaffold as a Tumor Model
Mei Zhang et al.
INTERNATIONAL JOURNAL OF BIOMATERIALS (2013)
Three-Dimensional Spheroidal Culture Visualization of Membranogenesis of Bruch's Membrane and Basolateral Functions of the Retinal Pigment Epithelium
Rina Sato et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)
Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo
Keyang Huang et al.
ACS NANO (2012)
Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles
Hongliang Xin et al.
BIOMATERIALS (2012)
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
Maria Vinci et al.
BMC BIOLOGY (2012)
Advances in the formation, use and understanding of multi-cellular spheroids
Toni-Marie Achilli et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2012)
Microenvironment of alginate-based microcapsules for cell culture and tissue engineering
Xiaobo Huang et al.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2012)
Deconstructing the third dimension - how 3D culture microenvironments alter cellular cues
Brendon M. Baker et al.
JOURNAL OF CELL SCIENCE (2012)
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Geeta Mehta et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Light exposure and cell viability in fluorescence microscopy
H. Schneckenburger et al.
JOURNAL OF MICROSCOPY (2012)
A Heterogeneous In Vitro Three Dimensional Model of Tumour-Stroma Interactions Regulating Sprouting Angiogenesis
Pedro Correa de Sampaio et al.
PLOS ONE (2012)
Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay
Wan Yong Ho et al.
PLOS ONE (2012)
Multicellular Tumor Spheroids as an In Vivo-Like Tumor Model for Three-Dimensional Imaging of Chemotherapeutic and Nano Material Cellular Penetration
Hui-li Ma et al.
MOLECULAR IMAGING (2012)
Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration
Vikash P. Chauhan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery
Hong-Juan Yao et al.
BIOMATERIALS (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Live-cell 3D super-resolution imaging in thick biological samples
Francesca Cella Zanacchi et al.
NATURE METHODS (2011)
Preclinical development of molecular-targeted agents for cancer
Alberto Ocana et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2011)
High drug attrition rates-where are we going wrong?
Lisa Hutchinson et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2011)
The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy
Xinran Xiang et al.
PLOS ONE (2011)
Multiphoton Imaging of Actin Filament Formation and Mitochondrial Energetics of Human ACBT Gliomas
Yu-Jer Hwang et al.
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2011)
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
Britta Weigelt et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Multicellular tumor spheroids: An underestimated tool is catching up again
Franziska Hirschhaeuser et al.
JOURNAL OF BIOTECHNOLOGY (2010)
Tuning payload delivery in tumour cylindroids using gold nanoparticles
Byoungjin Kim et al.
NATURE NANOTECHNOLOGY (2010)
Anticancer drug development: the grand challenges
William N. Hait
NATURE REVIEWS DRUG DISCOVERY (2010)
Fibronectin Confers Survival Against Chemotherapeutic Agents But Not Against Radiotherapy in DU145 Prostate Cancer Cells: Involvement of the Insulin Like Growth Factor-1 Receptor
Francis Thomas et al.
PROSTATE (2010)
Can Animal Models of Disease Reliably Inform Human Studies?
H. Bart van der Worp et al.
PLOS MEDICINE (2010)
Imaging and Analysis of 3D Tumor Spheroids Enriched for a Cancer Stem Cell Phenotype
Fredika M. Robertson et al.
JOURNAL OF BIOMOLECULAR SCREENING (2010)
Three-dimensional context regulation of metastasis
Janine T. Erler et al.
CLINICAL & EXPERIMENTAL METASTASIS (2009)
In vitro spheroid model of placental vasculogenesis: does it work?
Nelli Baal et al.
LABORATORY INVESTIGATION (2009)
Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines
Wu Huanwen et al.
MOLECULAR CANCER (2009)
Spheroid-based drug screen: considerations and practical approach
Juergen Friedrich et al.
NATURE PROTOCOLS (2009)
Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
Dario Barbone et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Optimizing Environmental Scanning Electron Microscopy of Spheroidal Reaggregated Neuronal Cultures
Ivan S. Uroukov et al.
MICROSCOPY RESEARCH AND TECHNIQUE (2008)
A reliable tool to determine cell viability in complex 3-D culture: The acid phosphatase assay
Juergen Friedrich et al.
JOURNAL OF BIOMOLECULAR SCREENING (2007)
Engineering tumors with 3D scaffolds
Claudia Fischbach et al.
NATURE METHODS (2007)
Modeling tissue morphogenesis and cancer in 3D
Kenneth M. Yamada et al.
CELL (2007)
Multicellular spheroids as an in vitro model in experimental oncology: applications in translational medicine
Divya Khaitan et al.
EXPERT OPINION ON DRUG DISCOVERY (2006)
Tumor models for efficacy determination
Beverly A. Teicher
MOLECULAR CANCER THERAPEUTICS (2006)
Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy
D Khaitan et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2006)
Gene expression perturbation in vitro - A growing case for three-dimensional (3D) culture systems
A Birgersdotter et al.
SEMINARS IN CANCER BIOLOGY (2005)
Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids
M Wartenberg et al.
FEBS LETTERS (2005)
Possible future issues in the treatment of glioblastomas: Special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
F Lefranc et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Optical sectioning deep inside live embryos by selective plane illumination microscopy
J Huisken et al.
SCIENCE (2004)
Resistance of multicellular aggregates to pharmorubicin observed in human hepatocarcinoma cells
Z Jianmin et al.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2002)
Influence of refractive-index mismatch in high-resolution three-dimensional confocal microscopy
A Diaspro et al.
APPLIED OPTICS (2002)
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells
F Aoudjit et al.
ONCOGENE (2001)
Amino acid uptake and regulation in multicellular hepatoma spheroids
TM Pawlik et al.
JOURNAL OF SURGICAL RESEARCH (2000)
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