4.6 Review

Germinal Center Cells Turning to the Dark Side: Neoplasms of B Cells, Follicular Helper T Cells, and Follicular Dendritic Cells

期刊

FRONTIERS IN ONCOLOGY
卷 10, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.587809

关键词

peripheral T-cell lymphomas; angioimmunoblastic T cell lymphoma; follicular T-cell lymphoma; follicular dendritic cell sarcomas; follicular lymphoma; Burkitt lymphoma; diffuse large B cell lymphoma

类别

资金

  1. National Council for Science and Technology-CONACYT Mexico [221102]

向作者/读者索取更多资源

Understanding the malignant aspects of the three main cells involved in the GC reaction can provide insights into better treatments. Poorly studied neoplasms of Tfh cells and FDCs are clinically significant due to their aggressive behavior and metastatic potential. Better molecular and genetic characterization of these malignancies will lead to improved diagnosis and treatment.
Gaining knowledge of the neoplastic side of the three main cells-B cells, Follicular Helper T (Tfh) cells, and follicular dendritic cells (FDCs) -involved in the germinal center (GC) reaction can shed light toward further understanding the microuniverse that is the GC, opening the possibility of better treatments. This paper gives a review of the more complex underlying mechanisms involved in the malignant transformations that take place in the GC. Whilst our understanding of the biology of the GC-related B cell lymphomas has increased-this is not reviewed in detail here-the dark side involving neoplasms of Tfh cells and FDCs are poorly studied, in great part, due to their low incidence. The aggressive behavior of Tfh lymphomas and the metastatic potential of FDCs sarcomas make them clinically relevant, merit further attention and are the main focus of this review. Tfh cells and FDCs malignancies can often be misdiagnosed. The better understanding of these entities linked to their molecular and genetic characterization will lead to prediction of high-risk patients, better diagnosis, prognosis, and treatments based on molecular profiles.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据