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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Peter Friedl et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Interaction of tumor cells with the microenvironment
Hendrik Ungefroren et al.
CELL COMMUNICATION AND SIGNALING (2011)
RB1 and p53 at the crossroad of EMT and triple negative breast cancer
Zhe Jiang et al.
CELL CYCLE (2011)
Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer
Patricia M. McGowan et al.
MOLECULAR CANCER RESEARCH (2011)
Estrogen Induces c-myc Gene Expression via an Upstream Enhancer Activated by the Estrogen Receptor and the AP-1 Transcription Factor
Chunyu Wang et al.
MOLECULAR ENDOCRINOLOGY (2011)
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
Peng Jiang et al.
NATURE CELL BIOLOGY (2011)
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M. Nieman et al.
NATURE MEDICINE (2011)
Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo
Christian D. Young et al.
PLOS ONE (2011)
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
Cen Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
A Perspective on Cancer Cell Metastasis
Christine L. Chaffer et al.
SCIENCE (2011)
Signaling pathways in breast cancer metastasis - novel insights from functional genomics
Mario Andres Blanco et al.
BREAST CANCER RESEARCH (2011)
Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism
Anne S. Tibbetts et al.
ANNUAL REVIEW OF NUTRITION, VOL 30 (2010)
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation
Caryl J. Antalis et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian et al.
CELL (2010)
The autophagic tumor stroma model of cancer Role of oxidative stress and ketone production in fueling tumor cell metabolism
Stephanos Pavlides et al.
CELL CYCLE (2010)
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
Ubaldo E. Martinez-Outschoorn et al.
CELL CYCLE (2010)
LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest
Jennifer P. Morton et al.
GASTROENTEROLOGY (2010)
Microglia Promote Colonization of Brain Tissue by Breast Cancer Cells in a Wnt-Dependent Way
Tobias Pukrop et al.
GLIA (2010)
Metastatic Behavior of Breast Cancer Subtypes
Hagen Kennecke et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
Cesar A. Corzo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
R. J. DeBerardinis et al.
ONCOGENE (2010)
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
Sawako Suzuki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
Wenwei Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Selectins promote tumor metastasis
Heinz Laeubli et al.
SEMINARS IN CANCER BIOLOGY (2010)
Glutamine addiction: a new therapeutic target in cancer
David R. Wise et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
Zhaohui Feng et al.
TRENDS IN CELL BIOLOGY (2010)
American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer
M. Elizabeth H. Hammond et al.
JOURNAL OF ONCOLOGY PRACTICE (2010)
Does tumour dormancy offer a therapeutic target?
Paul E. Goss et al.
NATURE REVIEWS CANCER (2010)
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
T. Mashima et al.
BRITISH JOURNAL OF CANCER (2009)
Blinded by the Light: The Growing Complexity of p53
Karen H. Vousden et al.
CELL (2009)
The reverse Warburg effect Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Stephanos Pavlides et al.
CELL CYCLE (2009)
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Zachary T. Schafer et al.
NATURE (2009)
Genes that mediate breast cancer metastasis to the brain
Paula D. Bos et al.
NATURE (2009)
Conjugated Linoleic Acid (CLA) Inhibits Expression of the Spot 14 (THRSP) and Fatty Acid Synthase Genes and Impairs the Growth of Human Breast Cancer and Liposarcoma Cells
Christina Donnelly et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
Y. H. Zhao et al.
ONCOGENE (2009)
Meta-Analysis and Gene Set Enrichment Relative to ER Status Reveal Elevated Activity of MYC and E2F in the Basal Breast Cancer Subgroup
M. Chehani Alles et al.
PLOS ONE (2009)
Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment
Lauren K. Dunn et al.
PLOS ONE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Breast Cancer Molecular Subtypes in Patients With Locally Advanced Disease: Impact on Prognosis, Patterns of Recurrence, and Response to Therapy
Kathryn E. Huber et al.
SEMINARS IN RADIATION ONCOLOGY (2009)
Parallel progression of primary tumours and metastases
Christoph A. Klein
NATURE REVIEWS CANCER (2009)
Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes
Olafur Andri Stefansson et al.
BREAST CANCER RESEARCH (2009)
Subtypes of breast cancer show preferential site of relapse
Marcel Smid et al.
CANCER RESEARCH (2008)
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
Eiji Furuta et al.
CANCER RESEARCH (2008)
TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4
David Padua et al.
CELL (2008)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Expression of BRCAI protein in breast cancer and its prognostic significance
Emad A. Rakha et al.
HUMAN PATHOLOGY (2008)
AMP-activated protein kinase and human cancer: cancer metabolism revisited
F. P. Kuhajda
INTERNATIONAL JOURNAL OF OBESITY (2008)
The Tyrosine Kinase Receptor HER2 (erbB-2) From Oncogenesis to Adipogenesis
Alejandro Vazquez-Martin et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
Twisted epithelial-mesenchymal transition blocks senescence
Robert A. Weinberg
NATURE CELL BIOLOGY (2008)
P53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
Keiko Kawauchi et al.
NATURE CELL BIOLOGY (2008)
SREBPs: the crossroads of physiological and pathological lipid homeostasis
Rajendra Raghow et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2008)
Hypoxia and breast cancer: prognostic and therapeutic implications
K. Lundgren et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Models, mechanisms and clinical evidence for cancer dormancy
Julio A. Aguirre-Ghiso
NATURE REVIEWS CANCER (2007)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez et al.
NATURE REVIEWS CANCER (2007)
Organotropism of breast cancer metastasis
Xin Lu et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2007)
Detection and characterization of tumor hypoxia using pO2 histography
Peter Vaupel et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Mining gene expression profiles: expression signatures as cancer phenotypes
Joseph R. Nevins et al.
NATURE REVIEWS GENETICS (2007)
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
John D. Gordan et al.
CANCER CELL (2007)
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Karin Fischer et al.
BLOOD (2007)
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Gaorav P. Gupta et al.
NATURE (2007)
Adaptation of energy metabolism in breast cancer brain metastases
Emily I. Chen et al.
CANCER RESEARCH (2007)
New insights into the regulation of methyl group and homocysteine metabolism
Kelly T. Williams et al.
JOURNAL OF NUTRITION (2007)
The clinical significance of disseminated tumor cells in breast cancer
Martin J. Slade et al.
NATURE CLINICAL PRACTICE ONCOLOGY (2007)
The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis
Jianhua Wang et al.
CANCER AND METASTASIS REVIEWS (2006)
Regulation of AIF expression by p53
P. Stambolsky et al.
CELL DEATH AND DIFFERENTIATION (2006)
Bone marrow cells in the 'pre-metastatic niche': within bone and beyond
Rosandra N. Kaplan et al.
CANCER AND METASTASIS REVIEWS (2006)
Hypoxia-inducible factor-1α-expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
Daniele Generali et al.
CLINICAL CANCER RESEARCH (2006)
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
Karim Bensaad et al.
CELL (2006)
p53 regulates mitochondrial respiration
Satoaki Matoba et al.
SCIENCE (2006)
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer:: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
A Godoy et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Gonadal hormones determine sensitivity to central leptin and insulin
DJ Clegg et al.
DIABETES (2006)
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-α responsive promoters
ASL Cheng et al.
MOLECULAR CELL (2006)
Macrophage migration and gene expression in response to tumor hypoxia
C Murdoch et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer
DH Zhang et al.
MOLECULAR & CELLULAR PROTEOMICS (2005)
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
YB Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
T Porstmann et al.
ONCOGENE (2005)
A pooled analysis of bone marrow micrometastasis in breast cancer
S Braun et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
D Ponti et al.
CANCER RESEARCH (2005)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
JM Lizcano et al.
EMBO JOURNAL (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
AIF deficiency compromises oxidative phosphorylation
N Vahsen et al.
EMBO JOURNAL (2004)
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
E Svastová et al.
FEBS LETTERS (2004)
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
MN Corradetti et al.
GENES & DEVELOPMENT (2004)
Real-time quantitative PCR of telomere length
ME Gil et al.
MOLECULAR BIOTECHNOLOGY (2004)
Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?
G Gruber et al.
BREAST CANCER RESEARCH (2004)
Arginase in patients with breast cancer
Z Cavdar et al.
CLINICA CHIMICA ACTA (2003)
Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer
WD Foulkes et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2003)
Differential expression of GLUT12 in breast cancer and normal breast tissue
S Rogers et al.
CANCER LETTERS (2003)
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma
R Bos et al.
CANCER (2003)
Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer
D Rivenzon-Segal et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
YA Yang et al.
EXPERIMENTAL CELL RESEARCH (2002)
Epithelial-mesenchymal transitions in tumour progression
JP Thiery
NATURE REVIEWS CANCER (2002)
Lactate stimulates fibroblast expression of hyaluronan and CD44: The Warburg effect revisited
R Stern et al.
EXPERIMENTAL CELL RESEARCH (2002)
New therapeutics that modulate chemokine networks
MK Schwarz et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism
SR Eberhardy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells
PM Hwang et al.
NATURE MEDICINE (2001)
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis:: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
E Laughner et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Angiogenesis in cancer and other diseases
P Carmeliet et al.
NATURE (2000)
Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites
SB Xiong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)