期刊
CELLS
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cells10010010
关键词
chronic lymphocytic leukemia; cancer treatment; immunotherapy; interleukin-2; natural killer cells
类别
Clinical study demonstrates that combining low dose recombinant human IL-2 and low dose targeted therapy can achieve cytogenetic and molecular remission with minimal adverse events in patients with chronic lymphocytic leukemia (CLL).
Chronic lymphocytic leukemia (CLL) accounts for 10% of hematologic malignancies. CLL is a malignancy of CD5+ B cells and it is characterized by the accumulation of small, mature-appearing neoplastic lymphocytes in the blood, bone marrow, and secondary lymphoid tissues. In the present case, a middle-aged female patient with poor prognosis unmutated IGHV CLL achieved cytogenetic and molecular remission with minimal adverse events following six cycles of low dose recombinant human IL-2 (rIL-2) in combination with low dose targeted venetoclax. Personalized low dose rIL-2 in combination with either lenalidomide or venetoclax mediates natural killer stimulation and is an effective non-toxic immunotherapy administered in the outpatient setting for poor prognosis CLL.
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