期刊
CELLS
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/cells9122602
关键词
PGLYRP1; cancer immunology; monocytes; TREM-1; cytokines; programmed cell death
类别
资金
- Ministry of Science and Higher Education Russian Federation [075-15-2020-773]
Studies on the mechanisms of activation of cytotoxic lymphocyte subpopulations are an important research direction in modern immunology. This study provides a detailed analysis of the effect of Tag7 (PGRP-S, PGLYRP1) on the development of lymphocyte subpopulations cytotoxic against MHC-negative tumor cells in a pool of peripheral blood mononuclear cells (PBMCs). The results show that Tag7 can bind to the TREM-1 receptor on the surfaces of monocytes, thereby triggering the expression of mRNA TNF alpha and IFN gamma. The appearance of these cytokines in conditioned medium leads to IL-2 cytokine secretion by CD3(+)CD4(+) lymphocytes. In turn, IL-2 facilitates unspecific activation of three cytotoxic cell subpopulations in the PBMC pool: NK (CD16(+)CD56(+)), CD3(+)CD4(+) and CD3(+)CD8(+). These subpopulations appear after a certain period of incubation with Tag7 and show toxicity against tumor cells.
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