期刊
CELLS
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/cells9122711
关键词
protocadherins; neurodevelopmental disorders; cell adhesion molecules; synaptic protein
类别
资金
- Telethon Foundation [GGP17283, GGP17260]
- PRIN [2017-20172C9HLW]
- Fondazione Le Jeune
- Fondazione Cariplo [2019-3438]
During brain development, neurons need to form the correct connections with one another in order to give rise to a functional neuronal circuitry. Mistakes during this process, leading to the formation of improper neuronal connectivity, can result in a number of brain abnormalities and impairments collectively referred to as neurodevelopmental disorders. Cell adhesion molecules (CAMs), present on the cell surface, take part in the neurodevelopmental process regulating migration and recognition of specific cells to form functional neuronal assemblies. Among CAMs, the members of the protocadherin (PCDH) group stand out because they are involved in cell adhesion, neurite initiation and outgrowth, axon pathfinding and fasciculation, and synapse formation and stabilization. Given the critical role of these macromolecules in the major neurodevelopmental processes, it is not surprising that clinical and basic research in the past two decades has identified several PCDH genes as responsible for a large fraction of neurodevelopmental disorders. In the present article, we review these findings with a focus on the non-clustered PCDH sub-group, discussing the proteins implicated in the main neurodevelopmental disorders.
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