4.6 Review

Stick around: Cell-Cell Adhesion Molecules during Neocortical Development

期刊

CELLS
卷 10, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/cells10010118

关键词

CAMs; classical cadherins; nectins; neocortical development; radial glia cells; neurons; neuronal migration; axon targeting; synaptogenesis; neurodevelopmental disorders

资金

  1. Ministerio de Ciencia e Innovacion (MICINN) [SAF2017-82880-R, FPI-PRE2018-086150]
  2. Garantia Juvenil contract from the Conselleria de Educacion de Valencia [GJIDI/2018/A/221]
  3. Spanish Ministerio de Ciencia e Innovacion (MICINN) [RYC-2015-19058]

向作者/读者索取更多资源

This review discusses the important role of cell-cell adhesion molecules in corticogenesis, focusing on the classical cadherins and nectins families and their effectors, with particular attention to the cooperative actions between the two families of C-CAMs.
The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to establish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contact with additional cells. In this review, we will focus on the role of two important families of cell-cell adhesion molecules (C-CAMs), classical cadherins and nectins, as well as in their effectors, in the control of fundamental processes related with corticogenesis, with special attention in the cooperative actions among the two families of C-CAMs.

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