期刊
CELLS
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cells10010042
关键词
mesenchymal stem cell; exosome; radiation damage
类别
资金
- National Natural Science Foundation of China [81773353, 81874254]
- Jilin Scientific and Technological Development Program [20190201204JC]
- Foundation of Scientific Research Planning Project of the 13th Five-year Plan of Jilin Provincial Department of Education [JJKH20201043KJ]
Radiation-induced damage is common in cancer patients undergoing radiotherapy, with mesenchymal stem cells and exosomes derived from them being ideal candidates for repair. Exosomes carry various bioactive substances that can affect immunomodulation, angiogenesis, cell survival, and proliferation, potentially providing new insights into the management of radiation damage.
Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for managing radiation-induced damage. Moreover, accumulating evidence suggests that exosomes derived from mesenchymal stem cells have a similar effect on repairing tissue damage mainly because these exosomes carry various bioactive substances, such as miRNAs, proteins and lipids, which can affect immunomodulation, angiogenesis, and cell survival and proliferation. Although the mechanisms by which mesenchymal stem cell-derived exosomes repair radiation damage have not been fully elucidated, we intend to translate their biological features into a radiation damage model and aim to provide new insight into the management of radiation damage.
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