4.6 Review

The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Sirtuin 3 is required for the protective effect of Resveratrol on Manganese-induced disruption of mitochondrial biogenesis in primary cultured neurons

Qian Sun et al.

Summary: The study found that resveratrol can alleviate manganese-induced neuronal injury and mitochondrial dysfunction by activating the SIRT1/PGC-1 alpha signaling pathway, with SIRT3 playing a key role in promoting mitochondrial biogenesis and reducing manganese-induced mitochondrial dysfunction.

JOURNAL OF NEUROCHEMISTRY (2021)

Review Cell Biology

Parkin, an E3 Ubiquitin Ligase, Plays an Essential Role in Mitochondrial Quality Control in Parkinson's Disease

Xiao-Le Wang et al.

Summary: Parkinson's disease, a complex neurodegenerative disorder affecting millions of aged individuals, has been linked to mitochondrial dysfunction. Mutations in genes associated with PD, such as Parkin, have been found to play a crucial role in mitochondrial quality control, suggesting potential therapeutic targets for the disease.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

Review Chemistry, Medicinal

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

Claudia Bento-Pereira et al.

Summary: Parkinson's disease is a progressive neurodegenerative disorder for which no disease-modifying therapies are available. Factors like age, genetic predisposition, and environmental stressors are known to increase the risk of developing PD. Activation of Nrf2 has shown to be beneficial in cellular and animal models of PD.

MEDICINAL RESEARCH REVIEWS (2021)

Review Genetics & Heredity

Autophagy in aging and longevity

Shi Q. Wong et al.

HUMAN GENETICS (2020)

Article Multidisciplinary Sciences

Metformin promotes mitophagy in mononuclear cells: a potential in vitro model for unraveling metformin's mechanism of action

Shipra Bhansali et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

Review Biochemistry & Molecular Biology

Mechanisms of Autophagy in Metabolic Stress Response

Angelina S. Gross et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

Review Neurosciences

PINK1-Parkin signaling in Parkinson's disease: Lessons from Drosophila

Yuzuru Imai

NEUROSCIENCE RESEARCH (2020)

Review Cell Biology

CD38 in Neurodegeneration and Neuroinflammation

Serge Guerreiro et al.

Review Biochemistry & Molecular Biology

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Shuya Kasai et al.

BIOMOLECULES (2020)

Article Multidisciplinary Sciences

Dual dynamics of mitochondrial permeability transition pore opening

Benjamin Wacquier et al.

SCIENTIFIC REPORTS (2020)

Review Cell Biology

Benefits of Metformin in Attenuating the Hallmarks of Aging

Ameya S. Kulkarni et al.

CELL METABOLISM (2020)

Review Pharmacology & Pharmacy

Distinct Types of Cell Death and the Implication in Diabetic Cardiomyopathy

Yun Chen et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Biophysics

Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria

Julian David C. Serna et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2020)

Article Cardiac & Cardiovascular Systems

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death

Michael J. Bround et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Review Food Science & Technology

Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

Xiao Meng et al.

Article Cell Biology

Dependence of PINK1 accumulation on mitochondrial redox system

Feng Gao et al.

AGING CELL (2020)

Article Biochemistry & Molecular Biology

PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics

Hailong Han et al.

EMBO REPORTS (2020)

Review Neurosciences

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease?

Darren M. O'Hara et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Physiology

Cyclophilin D: An Integrator of Mitochondrial Function

Georgios Amanakis et al.

FRONTIERS IN PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Inflammasome and Mitophagy Connection in Health and Disease

Jae-Min Yuk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Endocrinology & Metabolism

Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges

Rong Yu et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Biochemistry & Molecular Biology

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Massimo Bonora et al.

BIOMOLECULES (2020)

Review Nutrition & Dietetics

Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

Diana Zukas Andreotti et al.

FRONTIERS IN NUTRITION (2020)

Article Cardiac & Cardiovascular Systems

Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

Michela Carraro et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Article Cell Biology

Autophagy-Sirt3 axis decelerates hematopoietic aging

Yixuan Fang et al.

AGING CELL (2020)

Article Biochemistry & Molecular Biology

The mitochondrial permeability transition pore: Is it formed by the ATP synthase, adenine nucleotide translocators or both?

Christopher P. Baines et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2020)

Review Medicine, Research & Experimental

PINK1: The guard of mitochondria

Nan Wang et al.

LIFE SCIENCES (2020)

Review Geriatrics & Gerontology

The effect of fasting or calorie restriction on mitophagy induction: a literature review

Sanaz Mehrabani et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2020)

Article Biochemistry & Molecular Biology

Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells

Luoyao Yang et al.

REDOX BIOLOGY (2020)

Article Oncology

Dynamic modulation of autophagy: implications for aging and cancer

Liam D. Cassidy et al.

MOLECULAR & CELLULAR ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Eunju Lee et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Geriatrics & Gerontology

Metformin as a geroprotector: experimental and clinical evidence

Veronika Piskovatska et al.

BIOGERONTOLOGY (2019)

Review Biochemistry & Molecular Biology

Toward understanding genomic instability, mitochondrial dysfunction and aging

Nima B. Fakouri et al.

FEBS JOURNAL (2019)

Article Biochemistry & Molecular Biology

Dynamics of the mitochondrial permeability transition pore: Transient and permanent opening events

Liron Boyman et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

Article Biochemistry & Molecular Biology

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

Ben Zhou et al.

Article Biochemistry & Molecular Biology

Mitochondrial aquaporin-8 is involved in SREBP-controlled hepatocyte cholesterol biosynthesis

Mauro Danielli et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Pharmacology & Pharmacy

Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury

Ahmed A. Mohsin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Article Gastroenterology & Hepatology

AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species

Stephanie J. King et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)

Review Cell Biology

The molecular machinery of regulated cell death

Daolin Tang et al.

CELL RESEARCH (2019)

Review Cell Biology

The Mitochondrial Permeability Transition in Mitochondrial Disorders

Justina Sileikyte et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Cell Biology

Current Progress of Mitochondrial Quality Control Pathways Underlying the Pathogenesis of Parkinson's Disease

Xue Jiang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Cell Biology

The Good and the Bad of Mitochondrial Breakups

Hans-Georg Sprenger et al.

TRENDS IN CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

Jason Karch et al.

SCIENCE ADVANCES (2019)

Review Cell Biology

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

Akshay Bareja et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Spermidine ameliorates liver ischaemia-reperfusion injury through the regulation of autophagy by the AMPK-mTOR-ULK1 signalling pathway

Hao Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Genetics & Heredity

TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging

T. Keith Blackwell et al.

GENETICS (2019)

Review Biochemistry & Molecular Biology

The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson's Disease

Kai-Jung Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

Hanlin Zhang et al.

MOLECULAR CELL (2019)

Review Cell Biology

Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging

Ne N. Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Endocrinology & Metabolism

Metformin as Anti-Aging Therapy: Is It for Everyone?

Alexander A. Soukas et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Article Cell Biology

Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

Helena Aspernig et al.

CELL REPORTS (2019)

Review Biochemistry & Molecular Biology

DNA damage responses in ageing

Paulo F. L. da Silva et al.

OPEN BIOLOGY (2019)

Review Cell Biology

Agephagy - Adapting Autophagy for Health During Aging

Eleanor R. Stead et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Autophagy-dependent cell death

Donna Denton et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Pharmacology & Pharmacy

Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 β pathway

Mengyuan Tian et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Redox regulation by NRF2 in aging and disease

Cody J. Schmidlin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease

Fiona Bonello et al.

HUMAN MOLECULAR GENETICS (2019)

Article Cell Biology

Temporal integration of mitochondrial stress signals by the PINK1:Parkin pathway

J. Logan Bowling et al.

BMC MOLECULAR AND CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Mammalian mitophagy - from invitro molecules to invivo models

Catherine E. Rodger et al.

FEBS JOURNAL (2018)

Review Biochemistry & Molecular Biology

The role of mitochondrial ROS in the aging brain

Rhoda Stefanatos et al.

FEBS LETTERS (2018)

Review Geriatrics & Gerontology

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

Thomas Weichhart

GERONTOLOGY (2018)

Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Cell Biology

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Tomer Shpilka et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Cell Biology

Nrf2: Molecular and epigenetic regulation during aging

A. Silva-Palacios et al.

AGEING RESEARCH REVIEWS (2018)

Review Cell Biology

Mitochondria and aging: A role for the mitochondrial transition pore?

Mathieu Panel et al.

AGING CELL (2018)

Article Cell Biology

A mitochondrial delicacy: dynamin-related protein 1 and mitochondrial dynamics

Mason T. Breitzig et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

The Role of Sirtuins in Antioxidant and Redox Signaling

Chandra K. Singh et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Pharmacology & Pharmacy

Current mechanistic insights into the CCCP-induced cell survival response

Mariame Selma Kane et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Sarah Pickles et al.

CURRENT BIOLOGY (2018)

Review Clinical Neurology

Mitochondrial Dysfunction in Parkinson's Disease: New Mechanistic Insights and Therapeutic Perspectives

Jin-Sung Park et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

Review Biochemistry & Molecular Biology

The role of Nrf2 signaling in counteracting neurodegenerative diseases

Albena T. Dinkova-Kostova et al.

FEBS JOURNAL (2018)

Review Biochemistry & Molecular Biology

Determinants of dopaminergic neuron loss in Parkinson's disease

Dalton James Surmeier

FEBS JOURNAL (2018)

Article Medicine, Research & Experimental

SIRT3 deficiency exacerbates p53/Parkin-mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts

Yan Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Review Cell Biology

Recent insights into the cellular and molecular determinants of aging

Linhao Ruan et al.

JOURNAL OF CELL SCIENCE (2018)

Article Cardiac & Cardiovascular Systems

Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides

James Boslett et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

Review Cell Biology

Mitophagy and the release of inflammatory cytokines

James Harris et al.

MITOCHONDRION (2018)

Review Cell Biology

Autophagy as a promoter of longevity: insights from model organisms

Malene Hansen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Physiology

NEURONAL CELL DEATH

Michael Fricker et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Multidisciplinary Sciences

Identification of a highly neurotoxic alpha-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease

Diego Grassi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease

Marthe H. R. Ludtmann et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging

Marioly Mueller et al.

FRONTIERS IN NEUROSCIENCE (2018)

Review Genetics & Heredity

The Aging Mitochondria

Pierre Theurey et al.

Review Endocrinology & Metabolism

Aging Hallmarks: The Benefits of Physical exercise

Alexandre Rebelo-Marques et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Medicine, Research & Experimental

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

Dong Hwan Ho et al.

EXPERIMENTAL NEUROBIOLOGY (2018)

Review Biochemistry & Molecular Biology

Nuclear Genomic Instability and Aging

Laura J. Niedernhofer et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Cardiac & Cardiovascular Systems

AMPK2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

Bei Wang et al.

CIRCULATION RESEARCH (2018)

Article Cardiac & Cardiovascular Systems

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases

Alice E. Kane et al.

CIRCULATION RESEARCH (2018)

Article Cardiac & Cardiovascular Systems

Autophagy in Cardiovascular Aging

Mahmoud Abdellatif et al.

CIRCULATION RESEARCH (2018)

Review Pharmacology & Pharmacy

Mitochondrial permeability transition pore: a potential drug target for neurodegeneration

Komal Kalani et al.

DRUG DISCOVERY TODAY (2018)

Review Biochemistry & Molecular Biology

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

Russel J. Reiter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Cell Biology

Autophagy-dependent cell death - where, how and why a cell eats itself to death

Shani Bialik et al.

JOURNAL OF CELL SCIENCE (2018)

Article Multidisciplinary Sciences

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Alvaro F. Fernandez et al.

NATURE (2018)

Review Cell Biology

Autophagy and the cell biology of age-related disease

Andrew M. Leidal et al.

NATURE CELL BIOLOGY (2018)

Review Hematology

DNA damage responses and p53 in the aging process

Hui-Ling Ou et al.

Review Medicine, General & Internal

The role of mitochondrial dysfunction in cardiovascular disease: a brief review

Dimitry A. Chistiakov et al.

ANNALS OF MEDICINE (2018)

Editorial Material Cell Biology

NAD+: The convergence of DNA repair and mitophagy

Evandro F. Fang et al.

AUTOPHAGY (2017)

Review Pharmacology & Pharmacy

New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases

Fabio Di Lisa et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Meeting Abstract Geriatrics & Gerontology

Genome instability: A conserved mechanism of aging?

Jan Vijg

EXPERIMENTAL GERONTOLOGY (2017)

Article Biochemistry & Molecular Biology

Caloric restriction protects livers from ischemia/reperfusion damage by preventing Ca2+- induced mitochondrial permeability transition

Sergio L. Menezes-Filho et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin

Bin Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex II

Paavo Korge et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex III

Paavo Korge et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

Hoi-Shan Wong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Cell Biology

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

Jonathon L. Burman et al.

JOURNAL OF CELL BIOLOGY (2017)

Article Biology

A radical shift in perspective: mitochondria as regulators of reactive oxygen species

Daniel Munro et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2017)

Article Neurosciences

Proteostasis and ageing: insights from long-lived mutant mice

William A. Sands et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

Review Cell Biology

The role of the TOR pathway in mediating the link between nutrition and longevity

Oleh Lushchak et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2017)

Review Biochemistry & Molecular Biology

Mitophagy in neurodegeneration and aging

Elayne M. Fivenson et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

Article Multidisciplinary Sciences

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

David M. Sabatini

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease

Brianada Koentjoro et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Oxidative Stress

Helmut Sies et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)

Article Biochemistry & Molecular Biology

Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition

Andrea Guidarelli et al.

BIOFACTORS (2017)

Review Cell Biology

Dietary restriction and lifespan: Lessons from invertebrate models

Pankaj Kapahi et al.

AGEING RESEARCH REVIEWS (2017)

Review Biochemistry & Molecular Biology

Non-apoptotic functions of BCL-2 family proteins

Atan Gross et al.

CELL DEATH AND DIFFERENTIATION (2017)

Review Neurosciences

Parkin and PINK1 functions in oxidative stress and neurodegeneration

Sandeep K. Barodia et al.

BRAIN RESEARCH BULLETIN (2017)

Article Biochemistry & Molecular Biology

Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells

Audrey V. Kuznetsov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2017)

Review Biochemistry & Molecular Biology

Integrating the UPRmt into the mitochondrial maintenance network

Christopher J. Fiorese et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

Review Cell Biology

PINK1 and Parkin: emerging themes in mitochondrial homeostasis

Thomas G. McWilliams et al.

CURRENT OPINION IN CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

The cyclophilin D/Drp1 axis regulates mitochondrial fission contributing to oxidative stress-induced mitochondrial dysfunctions in SH-SY5Y cells

Anqi Xiao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Yongjie Wei et al.

Review Cell Biology

Mammalian Mitochondria and Aging: An Update

Timo E. S. Kauppila et al.

CELL METABOLISM (2017)

Article Neurosciences

Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability

Chuen-Lin Huang et al.

MOLECULAR NEUROBIOLOGY (2016)

Review Biochemistry & Molecular Biology

Mitophagy: a balance regulator of NLRP3 inflammasome activation

Min-Ji Kim et al.

BMB REPORTS (2016)

Article Biochemistry & Molecular Biology

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

Carsten Merkwirth et al.

Article Biochemistry & Molecular Biology

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

Lianfeng Wu et al.

Editorial Material Cell Biology

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

Chen-Song Zhang et al.

CELL METABOLISM (2016)

Article Cell Biology

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

Filippo Scialo et al.

CELL METABOLISM (2016)

Article Biochemistry & Molecular Biology

Nrf2 protects mitochondrial decay by oxidative stress

Joshua Strom et al.

FASEB JOURNAL (2016)

Article Biochemistry & Molecular Biology

Manganese ions enhance mitochondrial H2O2 emission from Krebs cycle oxidoreductases by inducing permeability transition

Erik Bonke et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Review Biochemistry & Molecular Biology

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Martin D. Brand

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Allergy

Regulation of inflammasomes by autophagy

Tatsuya Saitoh et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression

Amrita Datta Chaudhuri et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

Danya Ben-Hail et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Geriatrics & Gerontology

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Sebastian I. Arriola Apelo et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

Review Biochemistry & Molecular Biology

Mitophagy plays a central role in mitochondrial ageing

Alan Diot et al.

MAMMALIAN GENOME (2016)

Review Biochemistry & Molecular Biology

The Mitochondrial Basis of Aging

Nuo Sun et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

Urolithin A induces mitophagy and prolongs lifespan in C-elegans and increases muscle function in rodents

Dongryeol Ryu et al.

NATURE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Cardioprotection and lifespan extension by the natural polyamine spermidine

Tobias Eisenberg et al.

NATURE MEDICINE (2016)

Review Cell Biology

Nuclear DNA damage signalling to mitochondria in ageing

Evandro Fei Fang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Erin Quan Toyama et al.

SCIENCE (2016)

Review Cell Biology

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties

Valentina Izzo et al.

TRENDS IN CELL BIOLOGY (2016)

Review Geriatrics & Gerontology

It takes two to tango: NAD+ and sirtuins in aging/longevity control

Shin-ichiro Imai et al.

NPJ AGING AND MECHANISMS OF DISEASE (2016)

Review Cell Biology

DNA repair and aging: the impact of the p53 family

Sara Nicolai et al.

AGING-US (2015)

Review Biochemistry & Molecular Biology

Dietary restriction, mitochondrial function and aging: from yeast to humans

Andrea Ruetenik et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Brendan A. I. Payne et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Article Biochemistry & Molecular Biology

The role of mitochondrial dysfunction in age-related diseases

Rebecca K. Lane et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Review Biochemistry & Molecular Biology

Mitochondrial ROS Signaling in Organismal Homeostasis

Gerald S. Shadel et al.

Review Biochemistry & Molecular Biology

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Luigi Fontana et al.

Review Cardiac & Cardiovascular Systems

How Mitochondrial Dynamism Orchestrates Mitophagy

Orian S. Shirihai et al.

CIRCULATION RESEARCH (2015)

Article Cell Biology

PINK1/Parkin-mediated mitophagy in mammalian cells

Akinori Eiyama et al.

CURRENT OPINION IN CELL BIOLOGY (2015)

Article Cell Biology

ROS-dependent signal transduction

Colleen R. Reczek et al.

CURRENT OPINION IN CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Poly-ADP-ribosylation signaling during DNA damage repair

Barbara Golia et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2015)

Review Cell Biology

The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications

Thomas M. Durcan et al.

GENES & DEVELOPMENT (2015)

Review Medicine, Research & Experimental

Essential role for autophagy in life span extension

Frank Madeo et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Cardiac & Cardiovascular Systems

Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D

T. Bochaton et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Multidisciplinary Sciences

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling

Heide Christine Patterson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

Alban Ordureau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Genetics & Heredity

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Claire E. Schaar et al.

PLOS GENETICS (2015)

Review Geriatrics & Gerontology

Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri

Chiara Priami et al.

AGING AND DISEASE (2015)

Article Biochemistry & Molecular Biology

Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessed ex Vivo under Conditions Mimicking Rest and Exercise

Renata L. S. Goncalves et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

Article Cell Biology

The sirtuins, oxidative stress and aging: an emerging link

Philip I. Merksamer et al.

AGING-US (2013)

Review Biochemistry & Molecular Biology

Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

Tiago R. Figueira et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Crosstalk between apoptosis, necrosis and autophagy

Vassiliki Nikoletopoulou et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Review Biochemistry & Molecular Biology

Signaling the mitochondrial unfolded protein response

Mark W. Pellegrino et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Biochemistry & Molecular Biology

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

Laurie H. Sanders et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

Exploiting the Role of Resveratrol in Rat Mitochondrial Permeability Transition

Yue Zhang et al.

JOURNAL OF MEMBRANE BIOLOGY (2013)

Review Cell Biology

Changes in the mitochondrial permeability transition pore in aging and age-associated diseases

Giuseppe Paradies et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2013)

Article Cell Biology

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

Costanza Savino et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Article Cardiac & Cardiovascular Systems

ROS-Mediated PARP Activity Undermines Mitochondrial Function After Permeability Transition Pore Opening During Myocardial Ischemia-Reperfusion

Jacqueline M. Schriewer et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2013)

Article Biochemistry & Molecular Biology

Induction of the permeability transition pore in cells depleted of mitochondrial DNA

Ionica Masgras et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2012)

Article Biochemistry & Molecular Biology

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

Angelina V. Vaseva et al.

Article Multidisciplinary Sciences

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

Tomohiko Murakami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts

David Cotan et al.

FASEB JOURNAL (2011)

Article Biophysics

Influence of aging on membrane permeability transition in brain mitochondria

Julia Toman et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2011)

Review Biochemistry & Molecular Biology

Regulation of autophagy by ROS: physiology and pathology

Ruth Scherz-Shouval et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

Article Biochemistry & Molecular Biology

Cyclophilin D in mitochondrial pathophysiology

Valentina Giorgio et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Article Cardiac & Cardiovascular Systems

Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Giuseppe Petrosillo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Article Cell Biology

Coenzyme Q deficiency triggers mitochondria degradation by mitophagy

Angeles Rodriguez-Hernandez et al.

AUTOPHAGY (2009)

Article Cell Biology

Induction of autophagy by spermidine promotes longevity

Tobias Eisenberg et al.

NATURE CELL BIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening

Gurpreet S. Bhamra et al.

BASIC RESEARCH IN CARDIOLOGY (2008)

Article Biochemistry & Molecular Biology

Free radical scavenging action of the natural polyamine spermine in rat liver mitochondria

Irina G. Sava et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Review Biochemistry & Molecular Biology

The mitochondrial permeability transition from in vitro artifact to disease target

P Bernardi et al.

FEBS JOURNAL (2006)

Article Cardiac & Cardiovascular Systems

Exercise training induces respiratory substrate-specific decrease in Ca2+-induced permeability transition pore opening in heart mitochondria

M Marcil et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Review Cardiac & Cardiovascular Systems

Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition

F Di Lisa et al.

CARDIOVASCULAR RESEARCH (2005)

Article Biochemistry & Molecular Biology

Metformin inhibits mitochondrial permeability transition and cell death:: a pharmacological in vitro study

B Guigas et al.

BIOCHEMICAL JOURNAL (2004)

Article Biochemistry & Molecular Biology

The regulation of AMP-activated protein kinase by H2O2.

SL Choi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Article Neurosciences

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

R Betarbet et al.

NATURE NEUROSCIENCE (2000)