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TRENDS IN BIOCHEMICAL SCIENCES (2015)
Impaired intracellular trafficking defines early Parkinson's disease
Benjamin H. M. Hunn et al.
TRENDS IN NEUROSCIENCES (2015)
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Ian P. Johnson
FRONTIERS IN AGING NEUROSCIENCE (2015)
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Visible Virchow-Robin Spaces on Magnetic Resonance Imaging of Alzheimer's Disease Patients and Normal Elderly from the Sunnybrook Dementia Study
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ACTA RADIOLOGICA OPEN (2015)
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ALZHEIMERS & DEMENTIA (2014)
Impairment of Paravascular Clearance Pathways in the Aging Brain
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ANNALS OF NEUROLOGY (2014)
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BRAIN (2014)
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BRAIN (2014)
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BRAIN (2014)
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EXPERT OPINION ON THERAPEUTIC TARGETS (2014)
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18F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET
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In Vivo Imaging of Human Cholinergic Nerve Terminals with (-)-5-18F-Fluoroethoxybenzovesamicol: Biodistribution, Dosimetry, and Tracer Kinetic Analyses
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Neuroimaging in Parkinson disease: from research setting to clinical practice
Marios Politis
NATURE REVIEWS NEUROLOGY (2014)
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FRONTIERS IN AGING NEUROSCIENCE (2014)
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ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
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ALZHEIMERS & DEMENTIA (2013)
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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
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MOLECULAR NEURODEGENERATION (2013)
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NATURE REVIEWS NEUROSCIENCE (2013)
Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD
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An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
Mark J. Millan
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Microglia, Amyloid, and Glucose Metabolism in Parkinson's Disease with and without Dementia
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NEUROPSYCHOPHARMACOLOGY (2013)
Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
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PLOS ONE (2013)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Sleep Drives Metabolite Clearance from the Adult Brain
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SCIENCE (2013)
Is There a Cerebral Lymphatic System?
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STROKE (2013)
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TRENDS IN MOLECULAR MEDICINE (2013)
Molecular nexopathies: a new paradigm of neurodegenerative disease
Jason D. Warren et al.
TRENDS IN NEUROSCIENCES (2013)
Does variation in neurodegenerative disease susceptibility and phenotype reflect cerebral differences at the network level?
Andrew Eisen et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)
Sleep Quality and Preclinical Alzheimer Disease
Yo-El S. Ju et al.
JAMA NEUROLOGY (2013)
Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy
Johanna L. Crimins et al.
ACTA NEUROPATHOLOGICA (2012)
Metabolic brain networks in translational neurology: Concepts and applications
Martin Niethammer et al.
ANNALS OF NEUROLOGY (2012)
Targeting Mitochondria for Neuroprotection in Parkinson's Disease
Anthony Henry Vernon Schapira
ANTIOXIDANTS & REDOX SIGNALING (2012)
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
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BIOCHEMICAL JOURNAL (2012)
Decreased carbon-11-flumazenil binding in early Alzheimer's disease
Belen Pascual et al.
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Assessment of CSF Flow Dynamics Using PC-MRI in Spontaneous Intracranial Hypotension
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HEADACHE (2012)
Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rodent Brain
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Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation
Maria Jose Diogenes et al.
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Evidence That Sleep Deprivation Downregulates Dopamine D2R in Ventral Striatum in the Human Brain
Nora D. Volkow et al.
JOURNAL OF NEUROSCIENCE (2012)
Brain amyloid and cognition in Lewy body diseases
Stephen N. Gomperts et al.
MOVEMENT DISORDERS (2012)
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Harry Harris et al.
NATURE REVIEWS NEUROLOGY (2012)
Astrocyte-derived GDNF is a potent inhibitor of microglial activation
Sandra Moreira Rocha et al.
NEUROBIOLOGY OF DISEASE (2012)
The serotonergic system in ageing and Alzheimer's disease
Jose Julio Rodriguez et al.
PROGRESS IN NEUROBIOLOGY (2012)
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Jeffrey J. Iliff et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Sleep Deprivation Increases Cerebral Serotonin 2A Receptor Binding in Humans
David Elmenhorst et al.
SLEEP (2012)
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease (vol 2, e142, 2011)
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Mitochondrial Biology and Parkinson's Disease
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Inflammation and Adaptive Immunity in Parkinson's Disease
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Imaging of microglia in patients with neurodegenerative disorders
Marios Politis et al.
FRONTIERS IN PHARMACOLOGY (2012)
Mitochondrial Dysfunction in Neurodegenerative Diseases
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Dun-Sheng Yang et al.
AUTOPHAGY (2011)
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
Yaroslau Compta et al.
BRAIN (2011)
Cerebrospinal fluid flow imaging by using phase-contrast MR technique
B. Battal et al.
BRITISH JOURNAL OF RADIOLOGY (2011)
Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease
Isidre Ferrer et al.
JOURNAL OF NEURAL TRANSMISSION (2011)
α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death
Furong Cheng et al.
JOURNAL OF NEUROCHEMISTRY (2011)
HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration
Hui-Ming Gao et al.
JOURNAL OF NEUROSCIENCE (2011)
LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool
Giovanni Piccoli et al.
JOURNAL OF NEUROSCIENCE (2011)
Functional network disruption in the degenerative dementias
Michela Pievani et al.
LANCET NEUROLOGY (2011)
Glia: Initiators and Progressors of Pathology in Parkinson's Disease
Glenda M. Halliday et al.
MOVEMENT DISORDERS (2011)
Serotonergic mediated body mass index changes in Parkinson's disease
Marios Politis et al.
NEUROBIOLOGY OF DISEASE (2011)
Autophagy failure in Alzheimer's disease-locating the primary defect
Ralph A. Nixon et al.
NEUROBIOLOGY OF DISEASE (2011)
Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
Lydia Alvarez-Erviti et al.
NEUROSCIENCE RESEARCH (2011)
Assessing cerebrospinal fluid flow connectivity using 3D gradient echo phase contrast velocity encoded MRI
Henrik Odeen et al.
PHYSIOLOGICAL MEASUREMENT (2011)
Noradrenaline and Parkinson's disease
Claire Delaville et al.
FRONTIERS IN SYSTEMS NEUROSCIENCE (2011)
Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology
Karen A. Lewis et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Amyloid and Tau Proteins in Cortical Brain Biopsy and Alzheimer's Disease
Ville Leinonen et al.
ANNALS OF NEUROLOGY (2010)
Serotonin 2A Receptors and Visual Hallucinations in Parkinson Disease
Benedicte Ballanger et al.
ARCHIVES OF NEUROLOGY (2010)
Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction
Nicola Pavese et al.
BRAIN (2010)
Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia
Shigeki Hirano et al.
BRAIN (2010)
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Lars M. Ittner et al.
CELL (2010)
Mechanisms Underlying Inflammation in Neurodegeneration
Christopher K. Glass et al.
CELL (2010)
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems
Viktor I. Korolchuk et al.
FEBS LETTERS (2010)
Amyloid-beta and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline
P. Hemachandra Reddy et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson's Disease
Ashley D. Reynolds et al.
JOURNAL OF IMMUNOLOGY (2010)
CSF amyloid-β and tau proteins, and cognitive performance, in early and untreated Parkinson's Disease: the Norwegian ParkWest study
Guido Alves et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)
Staging of serotonergic dysfunction in Parkinson's Disease: An in vivo 11C-DASB PET study
Marios Politis et al.
NEUROBIOLOGY OF DISEASE (2010)
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
J. C. Klein et al.
NEUROLOGY (2010)
Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures
M. Politis et al.
NEUROLOGY (2010)
Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes
S. Gilman et al.
NEUROLOGY (2010)
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
Venu M. Nemani et al.
NEURON (2010)
Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5
Marianne Renner et al.
NEURON (2010)
Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
Brian R. Hoover et al.
NEURON (2010)
In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study
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PARKINSONISM & RELATED DISORDERS (2010)
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Jacqueline Burre et al.
SCIENCE (2010)
Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants
Marios Politis et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Reduced α4β2*-Nicotinic Acetylcholine Receptor Binding and Its Relationship to Mild Cognitive and Depressive Symptoms in Parkinson Disease
Philipp M. Meyer et al.
ARCHIVES OF GENERAL PSYCHIATRY (2009)
Anti-melanin antibodies are increased in sera in Parkinson's disease
K. L. Double et al.
EXPERIMENTAL NEUROLOGY (2009)
Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy
Barbara Borroni et al.
INTERNATIONAL PSYCHOGERIATRICS (2009)
A mathematical model of blood, cerebrospinal fluid and brain dynamics
Andreas A. Linninger et al.
JOURNAL OF MATHEMATICAL BIOLOGY (2009)
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport
Will Stoothoff et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation
Fabien Chauveau et al.
JOURNAL OF NUCLEAR MEDICINE (2009)
The locus coeruleus and noradrenergic modulation of cognition
Susan J. Sara
NATURE REVIEWS NEUROSCIENCE (2009)
Hyperstimulation of striatal D2 receptors with sleep deprivation: Implications for cognitive impairment
Nora D. Volkow et al.
NEUROIMAGE (2009)
Microglial activation and amyloid deposition in mild cognitive impairment A PET study
A. Okello et al.
NEUROLOGY (2009)
Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
H. Shimada et al.
NEUROLOGY (2009)
Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake
Shaomin Li et al.
NEURON (2009)
Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?
Kurt M. Lucin et al.
NEURON (2009)
Tiagabine Increases [11C] flumazenil Binding in Cortical Brain Regions in Healthy Control Subjects
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NEUROPSYCHOPHARMACOLOGY (2009)
Impaired cognitive performance in Parkinson's disease is related to caudate dopaminergic hypofunction and hippocampal atrophy
Pekka Jokinen et al.
PARKINSONISM & RELATED DISORDERS (2009)
MAM: more than just a housekeeper
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TRENDS IN CELL BIOLOGY (2009)
Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly
Howard Jay Aizenstein et al.
ARCHIVES OF NEUROLOGY (2008)
Acetylcholine receptors in dementia and mild cognitive impairment
Osama Sabri et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2008)
LRRK2 regulates synaptic vesicle endocytosis
Narae Shin et al.
EXPERIMENTAL CELL RESEARCH (2008)
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
Fiona Pickford et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
Nora D. Volkow et al.
JOURNAL OF NEUROSCIENCE (2008)
Neuroligins and neurexins link synaptic function to cognitive disease
Thomas C. Sudhof
NATURE (2008)
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Ganesh M. Shankar et al.
NATURE MEDICINE (2008)
Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction
Hwan-Ching Tai et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Imaging amyloid deposition in Lewy body diseases
S. N. Gomperts et al.
NEUROLOGY (2008)
Sigma-1 receptor chaperones at the ER-Mitochondrion interface regulate Ca2+ signaling and cell survival
Teruo Hayashi et al.
CELL (2007)
PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c
Hung-Li Wang et al.
NEUROBIOLOGY OF DISEASE (2007)
Interleukin-1 and inflammatory neurodegeneration
A. Simi et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
β-amyloid imaging and memory in non-demented individuals:: evidence for preclinical Alzheimer's disease
Kerryn E. Pike et al.
BRAIN (2007)
Apoptotic mechanisms in mutant LRRK2-mediated cell death
Ciro Iaccarino et al.
HUMAN MOLECULAR GENETICS (2007)
Visualization of hemodynamics in intracranial arteries using time-resolved three-dimensional phase-contrast MRI
Shuhei Yamashita et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2007)
Attenuation of the norepinephrine transporter activity and trafficking via interactions with α-synuclein
Christophe Wersinger et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
Henry Engler et al.
BRAIN (2006)
Dynamics of lateral ventricle and cerebrospinal fluid in normal and hydrocephalic brains
David C. Zhu et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2006)
Structural and functional features and significance of the physical linkage between ER and mitochondria
Gyorgy Csordas et al.
JOURNAL OF CELL BIOLOGY (2006)
Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study
Miia Kivipelto et al.
LANCET NEUROLOGY (2006)
Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein
Christophe Wersinger et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: Implications in physiological functions and in pathology
L Ciranna
CURRENT NEUROPHARMACOLOGY (2006)
Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia
NI Bohnen et al.
JOURNAL OF NEUROLOGY (2006)
Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models
M Day et al.
NATURE NEUROSCIENCE (2006)
Serotonin 1A receptors in the living brain of Alzheimer's disease patients
V Kepe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
In vivo imaging of microglial activation with [C-11](R)-PK11195 PET in progressive supranuclear palsy
A Gerhard et al.
MOVEMENT DISORDERS (2006)
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
A Petit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS
MR Turner et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2005)
Function of sigma1 receptors in Parkinson's disease
M Mishina et al.
ACTA NEUROLOGICA SCANDINAVICA (2005)
Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS:: studies with [11C]flumazenil PET
MR Turner et al.
BRAIN (2005)
Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system
P Remy et al.
BRAIN (2005)
Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease
NI Bohnen et al.
NEUROSCIENCE LETTERS (2005)
Aggregated α-synuclein activates microglia:: a process leading to disease progression in Parkinson's disease
W Zhang et al.
FASEB JOURNAL (2005)
[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS
MR Turner et al.
BRAIN (2005)
Pulsatile cerebrospinal fluid dynamics in the human brain
AA Linninger et al.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2005)
β-Site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
E Tamagno et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Microglial activation and dopamine terminal loss in early Parkinson's disease
Y Ouchi et al.
ANNALS OF NEUROLOGY (2005)
Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration
M Franceschi et al.
ANNALS OF NEUROLOGY (2005)
Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
LR Fischer et al.
EXPERIMENTAL NEUROLOGY (2004)
In vivo imaging of microglial activation with [11C](R)-PK 11195 PET in corticobasal degeneration
A Gerhard et al.
MOVEMENT DISORDERS (2004)
LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
R Deane et al.
NEURON (2004)
In vivo detection of microglial activation in frontotemporal dementia
A Cagnin et al.
ANNALS OF NEUROLOGY (2004)
α-Synuclein regulation of the dopaminergic transporter:: a possible role in the pathogenesis of Parkinson's disease
A Sidhu et al.
FEBS LETTERS (2004)
Huntington's disease: a synaptopathy?
JY Li et al.
TRENDS IN MOLECULAR MEDICINE (2003)
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
A Gerhard et al.
NEUROLOGY (2003)
Alzheimer's disease is a synaptic failure
DJ Selkoe
SCIENCE (2002)
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
DM Walsh et al.
NATURE (2002)
Positron emission tomography shows that impaired frontal lobe functioning in Parkinson's disease is related to dopaminergic hypofunction in the caudate nucleus
A Brück et al.
NEUROSCIENCE LETTERS (2001)
Direct binding and functional coupling of α-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
FJS Lee et al.
FASEB JOURNAL (2001)
Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity
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JOURNAL OF SLEEP RESEARCH (2000)
Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
M Shibata et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Neuroprotective and symptomatological action of memantine relevant for alzheimer's disease - a unified glutamatergic hypothesis on the mechanism of action
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NEUROTOXICITY RESEARCH (2000)
PET measures of benzodiazepine receptors in progressive supranuclear palsy
NL Foster et al.
NEUROLOGY (2000)