期刊
CANCERS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cancers13020216
关键词
multiple myeloma; bone marrow microenvironment; cytokine; cell adhesion; signal transduction
类别
资金
- National Institute of Health [R01-CA178264]
The bone marrow microenvironment in multiple myeloma is crucial for disease pathogenesis and involves complex interplay between different cells and signaling pathways. Development of combination treatment strategies to target these activated pathways is essential for improving patient outcomes.
Simple Summary The bone marrow (BM) microenvironment plays a crucial role in pathogenesis of multiple myeloma (MM), and delineation of the intracellular signaling pathways activated in the BM microenvironment in MM cells is essential to develop novel therapeutic strategies to improve patient outcome. The multiple myeloma (MM) bone marrow (BM) microenvironment consists of different types of accessory cells. Both soluble factors (i.e., cytokines) secreted from these cells and adhesion of MM cells to these cells play crucial roles in activation of intracellular signaling pathways mediating MM cell growth, survival, migration, and drug resistance. Importantly, there is crosstalk between the signaling pathways, increasing the complexity of signal transduction networks in MM cells in the BM microenvironment, highlighting the requirement for combination treatment strategies to blocking multiple signaling pathways.
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